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NCT01191827 Clinical Trial

fMRI Cholinergic Mechanisms in Schizophrenia

Schizophrenia Clinical Trial

Official title:
fMRI Cholinergic Mechanisms in Schizophrenia

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01191827
Other study ID # MHBB-011-07F
Secondary ID
Status Completed
Phase N/A
First received August 27, 2010
Last updated May 12, 2015
Start date October 2008
Est. completion date December 2011

Study information
Verified date May 2015
Source VA Office of Research and Development
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

This study aims to determine how clozapine treatment improves neuronal measures of sensory gating in subjects with schizophrenia.

Description:

This study will use functional magnetic resonance imaging (fMRI) to study patients treated with risperidone, a commonly used neuroleptic that does not improves sensory gating, to those treated with clozapine to determine which brain areas are involved in clozapine's normalization of sensory gating in schizophrenia.

Recruitment information / eligibility
Status Completed
Enrollment 40
Est. completion date December 2011
Est. primary completion date December 2011
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria:

- Diagnosis of schizophrenia

- age 18-60 yrs

Exclusion Criteria:

- claustrophobia

- weight > 250 lbs

- metal in body other than dental fillings

Study Design

Observational Model: Cohort, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Locations
Country Name City State
United States VA Eastern Colorado Health Care System, Denver Denver Colorado

Sponsors (1)
Lead Sponsor Collaborator
VA Office of Research and Development

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Neuronal Response During Sensory Gating Neuronal response (blood oxygenation level dependent functional magnetic resonance imaging signal, relative to the global mean) during sensory gating. Sensory gating is defined as the process of filtering out unnecessary environmental stimuli. Immediate No
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