Schizophrenia Clinical Trial
Official title:
N-methyl-D-aspartate (NMDA) Enhancers' Benefit to Schizophrenia Treatment
Hypofunction of N-methyl-D-aspartate (NMDA) receptor has been implicated in the pathophysiology of schizophrenia. To date, several reported trials on adjuvant NMDA-enhancing agents, including glycine and sarcosine (a glycine transporter I inhibitor), demonstrated clinical benefits for schizophrenia patients. This project aims to compare the efficacy and safety of sarcosine and combination of sarcosine and BE, as adjunctive therapy for schizophrenia, and to explore the possible synergistic effects of them. Sixty chronic schizophrenic inpatients will be enrolled in the 12-week double-blind, placebo-controlled trial. The participants receive stable antipsychotic regimens concomitant with sarcosine (2 g/d) (N=21), sarcosine(2 g/d) + BE(1 g/d ) (N=21), and placebo(N=21). Measures of clinical efficacy and side-effects were determined every 3 weeks. Measures of cognitive function were determined at the beginning and the end of the study. The efficacies of three groups are compared, and the characteristics of better responders are analyzed.
We will measure clinical efficacy every 3 weeks during the treatment. At the beginning and
the end of the trial,We will utilize a battery of tests to assess the effect of the
treatment on cognitive functions.The side effect assessments are also performed every 3
weeks. Side effect assessments include Simpson-Angus Rating Scale for extrapyramidal
side-effects, Abnormal Involuntary Movement Scale (AIMS) for dyskinesia, and Barnes
Akathisia Scale. Systemic side effects are reviewed by applying the Udvalg for Kliniske
Undersogelser (UKU) Side-effects Rating Scale. DAAO level, routine laboratory tests,
including CBC, biochemistry , urine analysis, and EKG, will be checked at baseline and the
end of week 12.
To compare the metabolic syndrome parameters among groups, body mass index, hip size, waist
size, blood pressure, fasting blood sugar, triglyceride, and total-cholesterol will be
checked at baseline and the end of the study.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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