Schizophrenia Clinical Trial
Official title:
Telmisartan as an Adjunctive Treatment for Metabolic Problems in Patients With Schizophrenia
This is a 12-week, randomized, double-blinded, placebo-controlled trial of telmisartan 80
mg/day as an adjunctive to clozapine or olanzapine therapy, in 70 schizophrenia subjects to
examine telmisartan's effect on glucose metabolism, weight, food intake, resting energy
expenditure, and body composition. In addition, the study will examine insulin's effects on
psychopathology and cognition.
Potential subjects will be identified by their clinicians at the Freedom Trail Clinic, or
Massachusetts General Hospital. Approximately 70 subjects will be enrolled.
The specific aims include:
Primary Aims:
1. Examine the efficacy of telmisartan added to regular doses of clozapine or olanzapine in
improving insulin resistance.
2. Examine the efficacy of telmisartan in reducing fasting triglycerides.
Secondary Aims:
1. Examine the effects of telmisartan on negative symptoms, positive symptoms, and
cognitive function.
2. Examine telmisartan's effects on lipids, body composition, and waist/hip ratio.
3. Examine telmisartan's effects on inflammatory biomarkers including C-reactive protein
(CRP) and interleukin 6 (IL-6).
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