Schizophrenia Clinical Trial
Official title:
Allopurinol in Schizophrenia: A Randomized Trial Administering Allopurinol vs Placebo as add-on Antipsychotics in Patients With Schizophrenia
The objective of the study is to evaluate the efficacy of allopurinol, compared to placebo, as add-on to anti-psychotics in the treatment of patients with schizophrenia.
An emerging body of evidence supports a purinergic hypothesis for schizophrenia. Adenosine
agonists have been shown to have properties similar to those of dopamine antagonists and
there is a well characterized antagonistic interaction between adenosine and dopamine
receptors in the ventral striatum1. Increased adenosinergic transmission has been
demonstrated to reduce the affinity of dopamine agonists for dopamine receptors. It has been
theorized that adenosine may exert some of its antipsychotic effects through modulation of
glutamatergic transmission.
Three double-blind, randomized, placebo-controlled trials have showed statistically
significant greater improvements in PANSS scores in the allopurinol groups vs. placebo
groups. These empiric data, together with the theoretical and basic science background
cited, provide the impetus for this proposed study.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
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