Schizophrenia Clinical Trial
Official title:
Cross-Sectional Study of the Association Between Multiple Genetic Polymorphisms and the Metabolic Side Effects in Patients With Schizophrenia Taking Clozapine More Than 1 Year
We are going to investigate the association of multiple genetic polymorphisms with the metabolic side effects in patients with schizophrenia taking clozapine.
The use of antipsychotics, especially clozapine and olanzapine is associated with metabolic
side effects, which put patients with schizophrenia at risk for cardiovascular morbidity or
diabetes.
The prevalence of the metabolic syndrome was 53.8% of patients who taking clozapine. The
high interindividual variability in antipsychotic-induced metabolic abnormalities suggests
that genetic makeup is a possible determinant.
The genotypes of the multiple gene such as HTR2C, LEP, adrenergic receptor,PPAR,GNB3 are
suggested to have associations with the metabolic side effects
(weight,glucose,lipid,BP,metabolic syndrome) in patients using antipsychotics.
We are going to investigate whether those multiple genetic polymorphisms are associated with
the metabolic side effects in patients taking clozapine.
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Observational Model: Cohort, Time Perspective: Cross-Sectional
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