Schizophrenia Clinical Trial
Official title:
Nicotine and Smoking Cessation in Schizophrenia
Many individuals with schizophrenia smoke cigarettes. Individuals in the schizophrenic population often find it difficult to quit smoking. The purpose of this trial is to determine the safety and effectiveness of bupropion in treating individuals with schizophrenia who smoke.
Schizophrenia affects 1 % of the population. Among individuals with schizophrenia, between
74 and 92 % smoke cigarettes regularly. Heavy smoking represents a significant and neglected
public health problem for people with schizophrenia; smoking cessation treatment is often
overlooked as part of the psychiatric care for such individuals.
The most effective treatment for smoking cessation described to date is sustained release
(SR) bupropion. Past research suggests that SR bupropion may be especially effective in
individuals with depressive symptoms, including individuals with schizophrenia. The purpose
of this trial is to evaluate the safety and efficacy of SR bupropion, when combined with
cognitive behavioral therapy (CBT), in individuals with schizophrenia.
This trial will last 12 weeks. Participants will be randomly assigned to receive SR
bupropion or placebo. All participants will receive weekly CBT. Participants will be
followed for 3 months following completion of the 12-week treatment session.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
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