Schizophrenia Clinical Trial
Official title:
Transcranial Magnetic Stimulation Used to Treat Auditory Hallucinations in Schizophrenia
Schizophrenia is a chronic, severe, and disabling brain disease. Auditory hallucinations are
the most frequent symptoms with an incident of 50% to 70% in patients.
Transcranial Magnetic Stimulation (TMS) can significantly reduce symptoms of schizophrenia.
TMS is capable of inducing changes in the electrical activities of the brain in humans.
The purpose of this trial is to study the use of TMS to decrease auditory hallucinations in
schizophrenia.
We hypothesize that: True treatment with rTMS will have significant decrease in auditory
hallucinations versus sham treatment over the temporoparietal cortex.
FMRI will highlight areas of activation with auditory hallucinations distinct from the area
identified by Hoffman's scalp based method.
Cortical inhibition as measured by paired pulse TMS will be increased after true TMS but not
sham TMS.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
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