Schizophrenia Clinical Trial
Official title:
A Psychopathological Study of Latent (Early) Schizophrenia: Clinical Pathology/Neuropsychological Dysfunctions
Current diagnostic criteria of schizophrenia are based on marked positive and negative
symptoms. This definition may impede the exploration of basic phenomenological
psychopathology or pathological mechanism of schizophrenia. Schizophrenia was found to have
neuroanatomical, neurophysiological and neuropsychological impairment. However, the
existence of these basic pathological states may not manifest as clinical state of
schizophrenia, and it is found in normal relatives of schizophrenia proband. The clinical
state of this underlying pathology may include so-called latent or early, or pseudo-neurotic
schizophrenia or schizotypal disorder. The manifestation of prominent neurotic symptom state
may not only present as an psychopathological issue, but also induce misdiagnosis in
clinical practice. This may interfere early diagnosis of schizophrenia and may delay the
chance of early and appropriate treatment.
Taking the fact of this disadvantaged conditions, this research is for exploration of
clinical pathology and neuropsychological functions of latent or pseudo-neurotic
schizophrenia. The strategy ia a natural follow-up study on the clinical cases obtained from
the registration record of the medical charts of the National Taiwan University Hospital
from 1970 to 1995. The natural follow-up results till study time (5 yrs to 30 yrs following
period) will be explored. By using neurotic group (50 cases), latent schizophrenia group (50
cases) and schizotypal group (30 cases), the differences in clinical pathology,
neuropsychological functions and family history of schizophrenia will be examined. There are
5 hypotheses to be tested: (1) Schizotaxia may exist as the manifestations of latent
schizophrenia, schizotypal disorder and frank schizophrenia. The severity of pathology
increased step by step; (2) The syndrome may change from the lower order to higher order to
higher order, but not all of them changed to the higher order; (3) The clinical pathology of
latent schizophrenia has both neurotic symptom as well as basic symptoms of schizophrenia;
(4) There is the same kind of neuropsychological impairment of schizophrenia in the group of
latent schizophrenia, and (5) The prevalence of schizophrenia in the first degree relatives
of latent schizophrenia is higher than that of the general population. Finally, this study
results will help the establishment of valid screening and/or diagnostic method (criteria)
of latent schizophrenia for clinical and research usage.
n/a
Observational Model: Defined Population, Time Perspective: Longitudinal
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