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Schizophrenia clinical trials

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NCT ID: NCT01057849 Recruiting - Schizophrenia Clinical Trials

Standard Comprehensive Intervention to Treat First-episode Schizophrenia

Start date: September 2008
Phase: N/A
Study type: Interventional

Schizophrenia is not a curable but a treatable disease by antipsychotics. Kinds of atypical antipsychotics are widely used since 1990s' in China. Although their efficacy for acute phase are all better than typicals, individulized regimen of them for first-episode schizophrenia and their effectiveness in real naturalistic clinical settings still remain unclear. And those patients also need more comprehensive intervention such as psychosocial programs to improve their function. This protocol is to conduct a study in several sites of China to investigate the effectiveness of comprehensive intervention combining sequenced atypical antipsychotic therapy and intensive psychosocial intervention for first-episode schizophrenic patients. In addition, this protocol also aims at collecting such information as molecular genetics, neurochemical test, neucognitive performance and neuroimaging for outcome analysis.

NCT ID: NCT01047215 Recruiting - Schizophrenia Clinical Trials

Heart Rate Changes in Schizophrenic and Bipolar Patients Under the Medication of Aripiprazole and Quetiapine

HeartAriQue
Start date: August 2009
Phase: Phase 4
Study type: Interventional

The goal of this research is investigating the heart rate changes in schizophrenic and bipolar patients under the medication of aripiprazole and quetiapine. In the mean time, we are hoping further investigating the interrelationship of medicine dosage and heart rate change, in order to acquire the best relationship both effectiveness as well as safety in acceptable heart rate change of clinical suggestion.

NCT ID: NCT01045824 Recruiting - Schizophrenia Clinical Trials

Family-based Genetic Long-term Study of Brain Function in Schizophrenia

FamilySchizo
Start date: January 2008
Phase: N/A
Study type: Observational

The goal of this research is to find out possible susceptible gene(s) in schizophrenic patients with family history and 5-year period functional changes of brain among the members of family, in order to further analysis factors and their interactions.

NCT ID: NCT01045720 Recruiting - Schizophrenia Clinical Trials

The Treatment of 2 Chinese Medicines in Clozapine-induced Hypersalivation in Schizophrenia

Start date: January 2010
Phase: Phase 2
Study type: Interventional

The goal of this research is hoping to combine traditional Chinese medicine medication and find out how to solve clozapine-induced hypersalivation, also reduce side-effect, medication compliance, improving life quality, improving social-function and reducing neopathy.

NCT ID: NCT01045629 Recruiting - Schizophrenia Clinical Trials

Competence Ability Study in People With Schizophrenia

CompSchizo
Start date: October 2009
Phase: N/A
Study type: Observational

The goal of this research is to understand whether schizophrenic patients are capable of comprehending clinical trial consent form or influenced by disease, also after intensified educational illustration for "understanding of consent form", their comprehension increased or not, in order to protect patient's right.

NCT ID: NCT01016145 Recruiting - Clinical trials for Schizophrenia or Schizoaffective Disorder

Identifying Predictors of Response to Antipsychotics Using a Treatment Algorithm

Start date: April 2009
Phase: Phase 4
Study type: Interventional

The objective of this study is to evaluate predictors of response to antipsychotic medication in subjects with schizophrenia. The investigators will evaluate psychopathology,brain MRI, genetics and neuropsychological profile. Two groups of treatment will be compared: first generation antipsychotics vs. second generation antipsychotics. Participants will be randomized to one of the groups. Trial duration: 12 weeks.

NCT ID: NCT00942981 Recruiting - Schizophrenia Clinical Trials

Functional Relevance of Dopamine Receptors in Healthy Controls and Patients With Schizophrenia: Characterization Through [11C]NNC-112 and [18F]Fallypride Positron Emission Tomography

Start date: November 13, 2009
Phase:
Study type: Observational

Background: - Some illnesses, such as schizophrenia, have effects on brain cells called dopamine receptors, which are required for normal brain function. People with schizophrenia have difficulty thinking and experience hallucinations and delusions. Medications that change brain dopamine receptors can decrease these hallucinations and delusions. - The cause of schizophrenia and its association with brain dopamine receptors is not known but may be clarified by studying dopamine receptors in people who have dopamine disorders (such as schizophrenia) and those who do not. Researchers are interested in studying the dopamine system to gain a better idea of how dopamine disorders develop, which may lead to better medical care for people with schizophrenia. Objectives: - To study the amount and distribution of two types of dopamine receptors. Eligibility: - Individuals between the ages of 18 and 60 who have schizophrenia. - Healthy volunteers between the ages of 18 and 90. Design: - Participants will undergo a full screening, with physical and psychological history, a neurological examination, and blood and urine samples. - Participants will have a blood flow map of the brain recorded with a positron emission tomography (PET) brain scan. A magnetic resonance imaging (MRI) scan will also be performed to determine brain anatomy. - To study the amount and distribution of dopamine receptors in the brain, participants will receive a small amount of a radioactive chemical in the vein, followed by a PET scan. - The procedure will be performed twice in two separate sessions, once for [18F]fallypride and once for [11C]NNC-112.

NCT ID: NCT00914030 Recruiting - Schizophrenia Clinical Trials

Visual Exploration and Attention: Studies in Patients With Schizophrenia and Autism Spectrum Disorders

Start date: June 2009
Phase: N/A
Study type: Observational

The aim of the protocol is to better understand the impairments in visual processing, as such impairments may induce social interaction difficulties in subjects with autism spectrum disorders (adults and children) and schizophrenia, like face exploration.The same protocol will be used for the three populations, each population being compared with matched controls. The explorations are designed to test two different hypotheses regarding the mechanisms of the visual perception difficulties of the two populations. Even though difficulties to extract the global form of objects have been described in both subjects with autism and schizophrenia, we will test two different hypotheses for the two populations. We will test the hypothesis that subjects with autism display an advantage for the processing of local information arising at an early level of processing, whereas disorders observed in patients with schizophrenia originate from attention disorders. The protocol includes three consecutive studies, each one being applied in each of the three populations.

NCT ID: NCT00894296 Recruiting - Schizophrenia Clinical Trials

Magnetoencephalographic (MEG) Correlates of Negative Symptoms in Patients Suffering From Schizophrenia and Their Influence by Add-on Treatments

Start date: March 2009
Phase: Phase 0
Study type: Observational

The objective of the suggested study is to identify changes in MEG correlates caused by the add-on treatment with the changes in negative symptoms of schizophrenia by comparing the change in the MEG correlates of the subjects before and during usage of new add on treatments for negative symptoms. The investigators hypothesize that the gravity of negative symptoms will correlate with a trend towards more aberrant electroencephalographic correlates mainly in continuous parameters, with an emphasis on alpha and delta bands

NCT ID: NCT00885716 Recruiting - Schizophrenia Clinical Trials

A Shared Decision Making Training for Inpatients With Schizophrenia

Start date: May 2009
Phase: N/A
Study type: Interventional

Patients suffering from schizophrenia who attend the communication skills program engage more deeply in therapeutic reasoning and treatment decisions. This results in stronger preferences to participate, greater perceived involvement and better long term adherence compared to patients who do not attend the training.