Schizophrenia, Undifferentiated Type Clinical Trial
Official title:
Comparison of the Effects of Aripiprazole and Risperidone on the Pattern of Brain Activation in Schizophrenic Patients During Emotional Tasks and With Reference to Controls
After an initial screening visit, including an assessment of psychiatric disorders, patients stabilized on antipsychotic medication (aripiprazole or risperidone) for at least 6 weeks and control subjects will undergo an assessment using functional magnetic resonance imaging (fMRI) of the differences of patterns of brain activation during an emotional task
This study is: interventional, comparative, open label, multi center, without experimental
treatment.
Main objective: To evaluate the effect of aripiprazole and risperidone on brain activation
during an emotional task of matching patients with schizophrenia, and in reference to
control subjects.
Secondary Objective: Comparison of emotional subjective and physiological perception in
patients with schizophrenia in relation with their treatment. Comparison of brain activation
in patients during the emotional induction task based on symptomatic dimensions, personality
traits and performance on cognitive and attentional tests, and for insight capacity .
Comparison of transcript level of candidate genes in blood mononuclear cells between the
study groups and study the interactions between the observed differences in brain imaging
and different levels of transcription of these genes.
;
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label