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Clinical Trial Summary

Tracking down the difficulties in metaphor comprehension experienced by individuals with schizophrenia across different metaphor types and exploring the neurological correlates via EEG recording technique


Clinical Trial Description

The investigators will address the following objectives: - Primary Objective: Tracking down the difficulties in metaphor comprehension experienced by individuals with schizophrenia across different metaphor types and exploring the neurological correlates via EEG recording technique - Secondary Objectives: 1) Evaluate the interactions between performances in metaphor comprehension and individual differences in psychopathology, cognition, ToM and functioning; 2) Test if the altered neurophysiological patterns associated to the fragility of metaphor comprehension in schizophrenia can be restored through a rehabilitative training The investigators will enroll 32 schizophrenic patients and 32 healthy subjects as control sample. Participants will undergo an initial visit with a specialist psychiatrist who will verify that their conditions meet the criteria required by the study. Then, subjects will be tested for metaphor comprehension, as well as for the other variables included in the study, and the electrical brain activity will be registered through a 128 channel EEG. In the check-up visits (i.e., after the training) the following data will be collected: - Scores relating to cognitive, pragmatic (understanding of metaphors), theory of mind and global functioning performance scores - EEG recordings related to the process of understanding metaphors - Scores on scales that evaluate psychopathological severity ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06375902
Study type Observational
Source IRCCS San Raffaele
Contact Mart Bosia, MD, PhD
Phone 00390226433299
Email bosia.marta@hsr.it
Status Not yet recruiting
Phase
Start date April 2024
Completion date October 2025

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