Clinical Trials Logo

Clinical Trial Summary

The purpose of this study is to test whether administration of levetiracetam (LEV), a commonly used anti-epileptic that alters neurotransmitter release, can reduce hippocampal hyperactivity. Specifically, we will utilize two functional magnetic resonance imaging (MRI) techniques: 1) blood oxygen level dependence (BOLD) contrast will assess activity with a visual scene processing task that engages the anterior hippocampus and 2) arterial spin labeling (ASL) will assess baseline activity. This study will also assess whether patients have improvement in their symptoms after receiving LEV. Previous studies in people with psychotic disorders have shown that the hippocampus is hyperactive and more activity correlates with worsening of clinical symptoms. Therefore, the aim of this study is to use an intervention to further understand the underlying mechanisms of the hippocampus in psychosis.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04277936
Study type Interventional
Source Vanderbilt University Medical Center
Contact
Status Terminated
Phase Phase 2
Start date May 11, 2020
Completion date August 31, 2020

See also
  Status Clinical Trial Phase
Completed NCT04559529 - Pharmacological Modulation of Hippocampal Activity in Psychosis 2 Phase 2
Recruiting NCT06134661 - Accelerated rTMS for Psychomotor Slowing N/A
Completed NCT05759091 - Effect of Applying Cognitive Defusion Techniques on Mindful Awareness, Cognitive Fusion and Believability of Delusions Among Clients With Schizophrenia N/A
Not yet recruiting NCT05995457 - The IM-ZBULLE Study : " Z-track " and " Airlock " Techniques During Intramuscular Injection of Haloperidol Decanoate N/A
Completed NCT04777266 - Music Therapy for People With Schizophrenia and Relates Psychosis. N/A
Not yet recruiting NCT05550155 - Efficacy of Maintenance Repetitive Transcranial Magnetic Stimulation (rTMS) in Auditory Verbal Hallucinations N/A
Active, not recruiting NCT04748679 - Cognitive Behavioral Therapy (CBT) Study Evaluating the Updating of Persecutory Beliefs N/A
Recruiting NCT05858255 - Hjernegym - Effects of Exergaming in Psychosis: a Clinical Intervention Study N/A
Not yet recruiting NCT05763966 - Uppsala Psychosis Cohort
Not yet recruiting NCT05731414 - Outcomes From Remediation and Behavioural Intervention Techniques N/A
Completed NCT04898270 - Adjunctive Use of Fute (Flupentixol) in Multi-acting Receptor-targeted Antipsychotics Treated Schizophrenia Patients Phase 4
Completed NCT04659161 - A Study to Assess Efficacy and Safety of KarXT in Acutely Psychotic Hospitalized Adult Patients With Schizophrenia (EMERGENT-2) Phase 3
Completed NCT04260763 - Evaluating a Novel Mobile App for Social Cognition in Psychosis N/A
Recruiting NCT04853485 - Repetitive Transcranial Magnetic Stimulation in Early Psychosis and The Functional Connectivity Biotypes N/A
Completed NCT04738123 - A Study to Assess Efficacy and Safety of KarXT in Acutely Psychotic Hospitalized Adult Patients With Schizophrenia (EMERGENT-3) Phase 3
Recruiting NCT05445180 - Investigating the Neural Correlates of Cognitive Function in Psychosis Patients and Non-Psychiatric Controls With Cannabis Use N/A
Completed NCT04773171 - Efficacy of Computer-assisted Cognitive Remediation in Patients With Schizophrenia N/A