Sars-CoV2 Clinical Trial
Official title:
"STUDY OF THE EFFICIENCY OF NORMAL HUMAN IMMUNOGLOBULINS (IVIG) IN PATIENTS AGED 75 YEARS AND OVER COVID-19 WITH SEVERE ACUTE RESPIRATORY FAILURE" GERONIMO 19
According to recent data, death rate is more than 20% for 75 years old hospitalized patients
and older.
In case of aggravation, according to the latest observations, if they are refused for
mechanical ventilation in intensive care, their death rate could reach 60% even for patients
without comorbidity.
Apart from an increase in oxygen therapy, no specific treatment is currently proposed.
The control of the inflammatory component seems to be a key element to be able to influence
the patients' health evolution.
Polyvalent intravenous immunoglobilins have immunomodulatory and anti-inflammatory properties
with a favorable safety profile for these elderly patients and several clinical cases lead to
positive impact in the caring for Covid patients.
This study objective is evaluation of the efficacy of polyvalent IVIg in combination with the
standard management of patients aged 75 and over with SARSCov2 infection with acute
respiratory failure (saturation ≤ 95%) requiring oxygen therapy> 5 L / min (i.e. patients
considered as moderate to severe ARDS according to the Berlin definition, Pa02 / Fi02≤200)
and disqualified from a care in the ICU.
n/a
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