Macrophage Regulation of Ozone-Induced Lung Inflammation — MOLI  

SARS-CoV-2 Pneumonia Clinical Trial

Official title: Macrophage Regulation of Ozone-Induced Lung Inflammation

Status Recruiting

Clinical Trial Summary

The purpose of this research study to understand how prior respiratory infections affect the susceptibility to lung inflammation following environmental exposures.

Clinical Trial Description

Study participants will undergo a 1-day screening that includes a blood draw and breathing testing, return for a two-day series of testing to include blood draw, and brief breathing test before and after an inhaled challenge with either filtered air (FA) or ozone (O3). Participants return the next day for a brief breathing test, a blood draw and a procedure called bronchoscopy to evaluate the lung after the challenge. Participants then return 18 - 20 days later to repeat the two-day series of testing to be challenged with the exposure not received on the first series, (FA or O3). Each visit will take about 3 - 3.5 hours. Follow-up phone calls from the study team will occur at 24 hours after each 2-day test series. Total study duration is about one to one-and a half months. ;

Related Conditions & MeSH terms

• Inflammation
• Pneumonia
• SARS-CoV-2 Pneumonia

• NCT number: NCT05773001
• Study type: Interventional
• Source: Duke University
• Contact: Claudia Salazar
• Phone: 9196602026
• Email: claudia.salazar@duke.edu
• Status: Recruiting
• Phase: Phase 1
• Start date: May 18, 2023
• Completion date: May 2028