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Clinical Trial Details — Status: Active, not recruiting

Administrative data

NCT number NCT05794412
Other study ID # 2022-01722
Secondary ID
Status Active, not recruiting
Phase
First received
Last updated
Start date January 10, 2023
Est. completion date May 31, 2024

Study information

Verified date January 2024
Source University Hospital, Geneva
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The goal of this observational study is to learn about the influence of pre-existing mucosal immunity, i.e. antibodies and immune cells that are present at the nasal mucosa before infection, on the infectious viral load after infection with SARS-CoV-2, influenza virus and RSV. The investigators will include app. 320 participants which will be followed for up to 17 months. During this time, the investigators will monitor their nasal mucosal antibodies at regular intervals and compare them to their infectious viral load if they are infected with SARS-CoV-2, influenza virus or RSV. Participants are invited to take a test for SARS-CoV-2, influenza virus or RSV in case of respiratory symptoms. If participants are positive the investigators will follow their viral load kinetics by taking nasopharyngeal swabs every 2-3 days. The investigators will also record the duration and strength of the following symptoms: - Cough - Fever - Tired - Sore throat - Difficulty breathing - Respiratory distress - Headache - Loss (or alteration) of smell - Loss (or alteration) of sense of taste - Myalgias - Chills - Subjective fever - Pink sputum (or coughing up blood) - Thoracic pain - Runny nose - Abdominal pain - Nausea - Vomiting - Diarrhea - Constipation - Irritated or watery eyes - Rashes - Other


Recruitment information / eligibility

Status Active, not recruiting
Enrollment 320
Est. completion date May 31, 2024
Est. primary completion date May 31, 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria: - In general good health, as determined by study investigators - All participants must be living in the canton of Geneva or working/studying in the canton of Geneva and living in neighboring communities that are within one hour travelling distance by car. Exclusion Criteria: - Inability to provide written consent. - Severely immunocompromised subjects as determined by the study investigator - Treated with inhaled drugs by nasal route within the last month

Study Design


Intervention

Other:
No intervention
No intervention

Locations

Country Name City State
Switzerland Geneva University Hospital Geneva

Sponsors (3)

Lead Sponsor Collaborator
University Hospital, Geneva ModernaTX, Inc., University of Geneva, Switzerland

Country where clinical trial is conducted

Switzerland, 

Outcome

Type Measure Description Time frame Safety issue
Primary SARS-CoV-2 infectious viral load up to 14 days post symptom onset
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