Sarcopenia Clinical Trial
Official title:
Sarcopenia and Diabetes Mellitus
The association of diabetes mellitus type 2 (T2DM) with sarcopenia has not been adequately investigated. Sarcopenia is characterized by progressive and generalized loss of skeletal muscle mass which may affect performance.
The relationship between DM and sarcopenia has not been extensively investigated. Skeletal
muscle is the primary site of glucose deposition, and decreased muscle mass plays a role in
impaired glucose metabolism in patients with insulin resistance and type 2 diabetes. Skeletal
muscle resistance to insulin action appears to be the link between type 2 diabetes (T2DM) and
sarcopenia. Hyperglycemia is a metabolic dysfunction which can potentially damage muscle
cells. Insulin deficiency leads to marked muscle catabolism that can be reversed by exogenous
insulin administration.
The metabolic disorder in diabetics may be reversible.Thus, it may be possible to restore
physical ability by restoring the musculoskeletal system.Therefore, the diagnosis of
sarcopenia if made can lead to interventions which may prevent the deterioration of body
composition and the subsequent deterioration of quality of life. According to the results of
the aforementioned studies it is still inconclusive if the metabolic disorder in diabetes may
be related to sarcopenia, or sarcopenia may be a consequence of diabetes.
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