Dendritic Cell Vaccination for Patients With Solid Tumors

Status Completed

Clinical Trial Summary

The aim of this study is to evaluate the immunogenicity and clinical efficacy of intradermal vaccination with autologous RNA-modified dendritic cells (DCs) - engineered to express the WT1 protein - in patients with limited spread metastatic solid tumors, i.e. breast cancers, glioblastoma grade IV, sarcomas, malignant mesothelioma and colorectal tumors. Based on the results of our previously performed phase I study with autologous WT1 mRNA-transfected DC, the investigators hypothesize that the vaccination with DC will be well-tolerated and will result in an increase in WT1-specific CD8+ T cell responses.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01291420
Study type	Interventional
Source	University Hospital, Antwerp
Contact
Status	Completed
Phase	Phase 1/Phase 2
Start date	May 3, 2010
Completion date	May 5, 2018

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