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Sarcoma, Alveolar Soft Part clinical trials

View clinical trials related to Sarcoma, Alveolar Soft Part.

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NCT ID: NCT05333458 Recruiting - Clinical trials for Advanced Soft Tissue Sarcoma

Testing Atezolizumab With or Without Selinexor in Patients >= 18 Years Old With Alveolar Soft Part Sarcoma, the Axiom Study

Start date: August 29, 2022
Phase: Phase 2
Study type: Interventional

This phase II trial tests whether atezolizumab alone or in combination with selinexor works to shrink tumors in patients with alveolar soft part sarcoma and whether the study drugs are better than the usual approach in treating this type of cancer. The usual approach is defined as care most people get for alveolar soft part sarcoma if they are not part of a clinical study, which includes treatment with radiation, kinase inhibitor drugs, immunotherapy drugs, or chemotherapy drugs. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Selinexor is in a class of medications called selective inhibitors of nuclear export (SINE). It works by blocking a protein called CRM1, which may help keep cancer cells from growing and may kill them. Giving atezolizumab alone or in combination with selinexor may help shrink tumors and stabilize the cancer in patients with alveolar soft part sarcoma.

NCT ID: NCT04999761 Recruiting - Colorectal Cancer Clinical Trials

AB122 Platform Study

Start date: June 1, 2021
Phase: Phase 1
Study type: Interventional

This is a phase 1, non-randomized open-label, multicenter platform study designed to evaluate the tolerability and safety of AB122 in patients with malignancies specified in each cohort.

NCT ID: NCT04332874 Recruiting - Sarcoma Clinical Trials

A Study of Pembrolizumab Plus Local Chemotherapy Using Isolated Limb Infusion (ILI) for Patients With Sarcoma in the Arm or Leg

Start date: April 1, 2020
Phase: Phase 2
Study type: Interventional

The purpose of this study is to find out whether giving the study drug pembrolizumab in combination with the chemotherapy drugs melphalan and dactinomycin, delivered directly to the affected arm or leg using a technique called isolated limb infusion (ILI), is a safe treatment that can delay the time before your disease gets worse (progresses).

NCT ID: NCT03967834 Recruiting - Soft Tissue Sarcoma Clinical Trials

Multimodal Immune Characterization of RAre Soft Tissue Sarcoma - MIRAS Project From SARRA (SARcome RAre) Project of the French Sarcoma Group

MIRAS
Start date: April 26, 2021
Phase: N/A
Study type: Interventional

This trial is a translational, open-label, multi-sites, prospective and retrospective cohort study of 500 patients aimed at clinical and biological characterization of sarcoma of rare subtype. 400 patients will be included in this prospective cohort study; they will be identified in the investigating centers in the context of either routine care or a clinical study protocol. Retrospective cases of patients (100 cases in total) will be identified in all centers through the GSF/GETO clinical databases already setted up (including the clinical base Conticabase).

NCT ID: NCT03623581 Recruiting - Clinical trials for Alveolar Soft Part Sarcoma

Clinical Trial in Chinese Patients of Elapsed/Metastatic/Unresectable Alveolar Soft Part Sarcoma(GB226)

Start date: September 6, 2018
Phase: Phase 2
Study type: Interventional

This study is a single-arm, phase 2 trial of Geptanolimab in patients with initially unresectable, recurrent or metastatic ASPS. The study aims to study the activity of Geptanolimab assessed per RECIST 1.1 and iRECIST criteria, and safety profile.

NCT ID: NCT03233698 Recruiting - Clinical trials for Metastatic Alveolar Soft Part Sarcoma

Atezolizumab in Treating Patients With Newly Diagnosed and Metastatic Alveolar Soft Part Sarcoma That Cannot Be Removed by Surgery

Start date: March 3, 2017
Phase: Phase 2
Study type: Interventional

This phase II trial studies how well atezolizumab works in treating patients with alveolar soft part sarcoma that has not been treated, has spread from where it started to other places in the body and cannot be removed by surgery. Monoclonal antibodies, such as atezolizumab, may allow the immune system cells to find and kill the tumor cells.

NCT ID: NCT01567046 Recruiting - Chordoma Clinical Trials

Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas

Start date: March 2012
Phase: N/A
Study type: Observational

This research trial studies genes in tissue samples from younger and adolescent patients with soft tissue sarcomas. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer