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Sirolimus in Cutaneous Sarcoidosis — SIRIUS  

Sarcoidosis Clinical Trial

Official title:
Cutaneous Sarcoidosis With Moderate to Severe Involvement of the Face : Multicenter Open-label Study of Oral Sirolimus Efficacy and Tolerance

Clinical Trial Summary

Sarcoidosis is a multisystemic disease of unknown etiology characterized by the presence of epithelioid granulomas without caseous necrosis in the organs involved. Sarcoidosis cutaneous lesions can be severe. There is no recommendation for the treatment of cutaneous sarcoidosis. A recent study highlights the potential efficacy of mTOR inhibitors in the treatment of sarcoidosis granulomas. The hypothesis is that sirolimus could be effective for sarcoidosis treatment, especially for cutaneous lesions. The main objective of this study is to evaluate sirolimus efficacy on cutaneous sarcoidosis of the face. The main evaluation criteria is the percentage of patients with a significant clinical response (relative decrease in "facial SASI" ≥ 25%) at week 16 of treatment.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05458492
Study type Interventional
Source Assistance Publique - Hôpitaux de Paris
Contact Jean-David Bouaziz, Pr
Phone +331 42 49 43 91
Email jean-david.bouaziz@aphp.fr
Status Not yet recruiting
Phase Phase 2
Start date July 2022
Completion date May 2027
View Details
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