A Study of Adalimumab to Treat Sarcoidosis of the Skin

Status Completed

Clinical Trial Summary

The purpose of this study is to determine if adalimumab is an effective for the skin manifestations of sarcoidosis.

Clinical Trial Description

The cutaneous lesions of sarcoidosis are often disfiguring and can produce functional impairment. They tend to be hard to treat with most topical therapies and often require systemic medications which carry the risk of significant side effects. Often such treatments are withheld unless there is a need to use them for visceral involvement. There is thus an unmet need for safe and effective treatments for these patients. In addition there is essentially no controlled trial data for any treatments for cutaneous sarcoidosis. This study is intended to determine if adalimumab might offer a viable therapeutic option for this condition by comparing the response of cutaneous sarcoid lesions to this drug as compared to placebo. ;

Study Design

Related Conditions & MeSH terms

Sarcoidosis

Clinical Trial Details

NCT number	NCT00274352
Study type	Interventional
Source	Pariser, Robert J., M.D.
Contact
Status	Completed
Phase	Phase 2
Start date	September 2006
Completion date	February 2012

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04008069` - Sarilumab in Patients With Glucocorticoid-Dependent Sarcoidosis	Phase 2
Recruiting	`NCT02807025` - Nasal, Tracheal and Bronchial Mucosal Lining Fluid(MLF) Sampling From Patients With Respiratory Diseases	N/A
Completed	`NCT01615484` - Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability	N/A
Completed	`NCT00326534` - Rickettsial Genesis to Sarcoidosis in Denmark	N/A
Completed	`NCT00373555` - Endobronchial Ultrasonography in the Diagnosis of Sarcoidosis	N/A
Recruiting	`NCT00470327` - A Study of the Natural Progression of Interstitial Lung Disease (ILD)
Completed	`NCT00512967` - The Occurence of Inflammation and Oxidative Stress in Lung Diseases	N/A
Recruiting	`NCT01745237` - Delayed-Enhancement Cardiovascular Magnetic Resonance in Patients With Sarcoidosis
Completed	`NCT00369980` - Diagnostic Usefulness of Fluorine–18-α–Methyltyrosine PET in Combination With 18F-FDG in Sarcoidosis Patient	N/A
Completed	`NCT00366509` - Role of Helicobacter Pylori and Its Toxins in Lung and Digestive System Diseases
Completed	`NCT00379275` - Eye and Immunogenetic Features of Sarcoidosis	N/A
Completed	`NCT04156789` - Obstructive Sleep Apnoea in Sarcoidosis
Recruiting	`NCT02916459` - EBUS-TBNA vs Flex 19G EBUS-TBNA	N/A
Recruiting	`NCT02827734` - Evaluation of Novel Lung Function Parameters in Patients With Interstitial Lung Disease (ILD)
Completed	`NCT02546388` - Somatostatin Receptor Imaging in Patients With Suspected Cardiac Sarcoidosis	N/A
Completed	`NCT01687517` - Efficacy and Safety of Influenza Vaccine During Sarcoidosis	Phase 3
Completed	`NCT01139710` - Sarcoidosis-associated Pulmonary Hypertension	N/A
Terminated	`NCT00747461` - Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD")	Phase 4
Completed	`NCT00555347` - Use of Armodafinil for Fatigue in Sarcoidosis	Phase 2/Phase 3
Completed	`NCT00073437` - A Study of Infliximab in Patients With Sarcoidosis	Phase 3