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NCT04462068 Clinical Trial

ACE and HLA Genotypes Predict Severity and Disease Progression in Danish Sarcoid Patients

Sarcoidosis Clinical Trial

Official title:
ACE and HLA Genotypes Predict Severity and Disease Progression in Danish Sarcoid Patients

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04462068
Other study ID # SAR3
Secondary ID
Status Completed
Phase
First received
Last updated
Start date December 1, 2019
Est. completion date November 30, 2023

Study information
Verified date May 2023
Source University of Aarhus
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Sarcoidosis is a multisystem granulomatous disease of unknown cause histologically characterized by noncaseating granulomas. Genetic factors affect disease course, which is highly variable and difficult to predict. This study aims to evaluate the predictive value of ACE and HLA genotypes on disease severity and progression in Danish patients with sarcoidosis.

Recruitment information / eligibility
Status Completed
Enrollment 150
Est. completion date November 30, 2023
Est. primary completion date November 30, 2023
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Diagnosis of sarcoidosis - Signed informed consent Exclusion Criteria: - Inability or unwillingness to adhere to the study - Inability to give informed consent

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Denmark Aarhus University Hospital. Dep. of Respiatory Diseases and Allergology Aarhus N

Sponsors (1)
Lead Sponsor Collaborator
University of Aarhus

Country where clinical trial is conducted

Denmark, 

Outcome
Type Measure Description Time frame Safety issue
Primary Time to initiation of treatment Time to initiation of systemic immunosuppression for sarcoidosis 1 year from diagnosis
Secondary Number of participants with extrapulmonary organ involvement Number of participants diagnosed with extrapulmonary organ involvement 1 year from diagnosis
Secondary Change in FEV1 Increase/ decline/ no change in FEV1 1 year
Secondary Change in FVC Increase/ decline/ no change in FVC 1 year
Secondary Change in diffusion capacity Increase/ decline/ no change in diffusion capacity 1 year
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