The Lung Microbiome in Sarcoidosis

Status Completed

Clinical Trial Summary

The objective of this study is to determine the presence of bacterial species, and the immunologic and molecular mechanisms of granuloma formation that might be involved in the pathogenesis of sarcoidosis. The investigators will collect peripheral blood and bronchoalveolar lavage fluid samples to isolate bacterial DNA and blood monocytes and lymphocytes. Specimens will be obtained from patients with sarcoidosis, with non-sarcoid lung disease, and healthy volunteers to directly compare the bacterial species present and the characteristics of cells thought to be involved in granuloma formation.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Sarcoidosis

Clinical Trial Details

NCT number	NCT02520323
Study type	Observational
Source	University of Michigan
Contact
Status	Completed
Phase	N/A
Start date	June 2015
Completion date	June 2017

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04008069` - Sarilumab in Patients With Glucocorticoid-Dependent Sarcoidosis	Phase 2
Recruiting	`NCT02807025` - Nasal, Tracheal and Bronchial Mucosal Lining Fluid(MLF) Sampling From Patients With Respiratory Diseases	N/A
Completed	`NCT01615484` - Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability	N/A
Completed	`NCT00274352` - A Study of Adalimumab to Treat Sarcoidosis of the Skin	Phase 2
Completed	`NCT00326534` - Rickettsial Genesis to Sarcoidosis in Denmark	N/A
Completed	`NCT00373555` - Endobronchial Ultrasonography in the Diagnosis of Sarcoidosis	N/A
Recruiting	`NCT00470327` - A Study of the Natural Progression of Interstitial Lung Disease (ILD)
Completed	`NCT00512967` - The Occurence of Inflammation and Oxidative Stress in Lung Diseases	N/A
Recruiting	`NCT01745237` - Delayed-Enhancement Cardiovascular Magnetic Resonance in Patients With Sarcoidosis
Completed	`NCT00369980` - Diagnostic Usefulness of Fluorine–18-α–Methyltyrosine PET in Combination With 18F-FDG in Sarcoidosis Patient	N/A
Completed	`NCT00379275` - Eye and Immunogenetic Features of Sarcoidosis	N/A
Completed	`NCT00366509` - Role of Helicobacter Pylori and Its Toxins in Lung and Digestive System Diseases
Completed	`NCT06396910` - TB and Sarcoidosis Granuloma
Completed	`NCT04156789` - Obstructive Sleep Apnoea in Sarcoidosis
Recruiting	`NCT02916459` - EBUS-TBNA vs Flex 19G EBUS-TBNA	N/A
Recruiting	`NCT02827734` - Evaluation of Novel Lung Function Parameters in Patients With Interstitial Lung Disease (ILD)
Completed	`NCT02546388` - Somatostatin Receptor Imaging in Patients With Suspected Cardiac Sarcoidosis	N/A
Completed	`NCT01687517` - Efficacy and Safety of Influenza Vaccine During Sarcoidosis	Phase 3
Completed	`NCT01139710` - Sarcoidosis-associated Pulmonary Hypertension	N/A
Terminated	`NCT00747461` - Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD")	Phase 4