Perfusion Analysis Using Rubidium in Cardiac Sarcoidosis

Status Completed

Clinical Trial Summary

The study aims at assessing diagnostic and therapeutic impact of Rubidium-82 PET in cardiac sarcoidosis.

Clinical Trial Description

The presence of cardiac involvement is a serious complication of sarcoidosis. Early diagnosis is challenging since it relies on an array of clinical, biological and imaging abnormalities. Myocardial perfusion imaging with sestamibi is currently a major feature of the diagnosis, since it allows to evidence both microcirculatory impairments and scar. However, some technical limitations are inherent to SPECT, mainly poor spatial resolution and lack of attenuation correction, resulting in the absence of flow quantification. Rubidium-82 (Rb) PET proved to be more sensitive and specific than sestamibi SPECT in the diagnosis of coronary artery disease. Furthermore, it allows noninvasive measurement of coronary flow reserve. Finally, it exposes patients to lower radiation dose than SPECT. Therefore, Rb PET may help to better identify cardiac involvement of sarcoidosis, and hence to better select those patients who require high-dose steroids. ;

Study Design

Related Conditions & MeSH terms

Sarcoidosis

Clinical Trial Details

NCT number	NCT01648933
Study type	Interventional
Source	Assistance Publique - Hôpitaux de Paris
Contact
Status	Completed
Phase	N/A
Start date	July 2012
Completion date	February 2017

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Perfusion Analysis Using Rubidium in Cardiac Sarcoidosis — PARCS

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms