Role of Proteomics in Diagnosing Sarcoidosis

Status Completed

Clinical Trial Summary

Sarcoidosis is a multi-systemic disorder, meaning that it can involve any organ in the body and that its clinical presentation is highly variable. In 90% of all sarcoidosis cases the lungs are affected. It is difficult to give a concise definition of sarcoidosis due to the fact that its exact cause is still unknown. Consequently, diagnosing the disease is also rather difficult. Up till now, sarcoidosis is generally diagnosed by using general clinical methods to evaluate the status of the lung including a chest X-ray, lung biopsy and bronchoalveolar lavage (BAL). However, some of these methods are considered to be rather invasive and, even more important, non-conclusive. Therefore, the current study has been designed to evaluate the use of a new technique, called SELDI-TOF mass spectrophotometry, for the diagnosis of sarcoidosis. This technique enables the analysis of all enzymes present in the blood of sarcoidosis patients which may hopefully lead to creating a disease-specific protein-profile that may facilitate the recognition of sarcoidosis. Moreover, these results will be compared with other currently used laboratory parameters.

Clinical Trial Description

n/a

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Sarcoidosis

Clinical Trial Details

NCT number	NCT00626938
Study type	Observational
Source	Maastricht University Medical Center
Contact
Status	Completed
Phase	N/A
Start date	March 2005
Completion date	March 2012

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04008069` - Sarilumab in Patients With Glucocorticoid-Dependent Sarcoidosis	Phase 2
Recruiting	`NCT02807025` - Nasal, Tracheal and Bronchial Mucosal Lining Fluid(MLF) Sampling From Patients With Respiratory Diseases	N/A
Completed	`NCT01615484` - Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability	N/A
Completed	`NCT00326534` - Rickettsial Genesis to Sarcoidosis in Denmark	N/A
Completed	`NCT00274352` - A Study of Adalimumab to Treat Sarcoidosis of the Skin	Phase 2
Completed	`NCT00373555` - Endobronchial Ultrasonography in the Diagnosis of Sarcoidosis	N/A
Recruiting	`NCT00470327` - A Study of the Natural Progression of Interstitial Lung Disease (ILD)
Completed	`NCT00512967` - The Occurence of Inflammation and Oxidative Stress in Lung Diseases	N/A
Recruiting	`NCT01745237` - Delayed-Enhancement Cardiovascular Magnetic Resonance in Patients With Sarcoidosis
Completed	`NCT00369980` - Diagnostic Usefulness of Fluorine–18-α–Methyltyrosine PET in Combination With 18F-FDG in Sarcoidosis Patient	N/A
Completed	`NCT00366509` - Role of Helicobacter Pylori and Its Toxins in Lung and Digestive System Diseases
Completed	`NCT00379275` - Eye and Immunogenetic Features of Sarcoidosis	N/A
Completed	`NCT06396910` - TB and Sarcoidosis Granuloma
Completed	`NCT04156789` - Obstructive Sleep Apnoea in Sarcoidosis
Recruiting	`NCT02916459` - EBUS-TBNA vs Flex 19G EBUS-TBNA	N/A
Recruiting	`NCT02827734` - Evaluation of Novel Lung Function Parameters in Patients With Interstitial Lung Disease (ILD)
Completed	`NCT02546388` - Somatostatin Receptor Imaging in Patients With Suspected Cardiac Sarcoidosis	N/A
Completed	`NCT01687517` - Efficacy and Safety of Influenza Vaccine During Sarcoidosis	Phase 3
Completed	`NCT01139710` - Sarcoidosis-associated Pulmonary Hypertension	N/A
Terminated	`NCT00747461` - Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD")	Phase 4