Sarcoidosis Clinical Trial
Official title:
Rickettsial Genesis to Sarcoidosis in Denmark
One study has suggested a connection between an infection with Rickettsia species and
sarcoidosis finding molecular evidence of rickettsial deoxyribonucleic acid (DNA) in two
patients. Another study found no antibodies in twenty Swedish patients with sarcoidosis.
This study will further enhance the subject by three different approaches in Danish
patients.
The purpose of this study is to find serological and molecular evidence of an infection with
Rickettsia species in Danish patients with sarcoidosis.
Status | Completed |
Enrollment | 36 |
Est. completion date | March 2009 |
Est. primary completion date | January 2009 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Referred to fiberoptic bronchoscopy in the department either because of sarcoidosis, hemoptysis, chronic cough, or cancer suspicion Exclusion Criteria: - Pregnant patients - Patients under the age of 18 - Patients without consent - Patients with a registered wish of not having their samples used for research |
Observational Model: Case Control, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Denmark | Denmark | Copenhagen S |
Lead Sponsor | Collaborator |
---|---|
Statens Serum Institut | Bispebjerg Hospital, Civilingeniør Johs. E. Ormstrup og Hustru Grete Ormstrups Fond |
Denmark,
Nilsson K, Påhlson C, Lukinius A, Eriksson L, Nilsson L, Lindquist O. Presence of Rickettsia helvetica in granulomatous tissue from patients with sarcoidosis. J Infect Dis. 2002 Apr 15;185(8):1128-38. Epub 2002 Mar 21. — View Citation
Planck A, Eklund A, Grunewald J, Vene S. No serological evidence of Rickettsia helvetica infection in Scandinavian sarcoidosis patients. Eur Respir J. 2004 Nov;24(5):811-3. — View Citation
Svendsen CB, Milman N, Høier-Madsen M, Dziegiel MH, Krogfelt KA. Determination of rickettsial and antinuclear antibodies in Danish patients with sarcoidosis. Clin Respir J. 2008 Oct;2(4):202-7. doi: 10.1111/j.1752-699X.2008.00051.x. — View Citation
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