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Safety and Pharmacokinetics of NP10679 in Normal Healthy Volunteers

Safety Issues Clinical Trial

Official title:
A Phase 1, Randomized , Double Blind, Single Ascending Dose Study to Investigate Safety, Tolerability and PK of NP10679 in Healthy Adults

Clinical Trial Summary

This study assesses the safety, tolerability and pharmacokinetics of NP10679 when delivered intravenously in escalating dose levels in comparison to placebo.

Clinical Trial Description

NP10679 is a pH dependent inhibitor of the GluN2B subtype of the NMDA receptor. Compounds of this drug class are hypothesized to be beneficial in a number of central nervous system disorders, including brain ischemia associated with subarachnoid hemorrhage, severe pain, major depression and substance abuse disorders. This study uses a double blind, adaptive design approach to evaluate the safety, tolerability and pharmacokinetics of a single dose of NP10679 when delivered intravenously in up to six escalating dose levels in comparison to placebo. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03565861
Study type Interventional
Source Neurop Inc.
Contact
Status Completed
Phase Phase 1
Start date April 6, 2018
Completion date October 10, 2018
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