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Clinical Trial Summary

ENKTL is a highly aggressive NHL with a higher incidence in Asia. L-asparaginase containing chemotherapy regimens are the standard first-line treatment with apparently toxicities. In 2020 ASH, the investigators reported Sintilimab(anti-PD-1 antibody) plus Chidamide(an oral subtype-selective HDACi) yielded effective antitumor activity, durable response in patients with relapsed or refractory ENKTL(SCENT trial. Abstracts 644). The investigators next conducted a exploratory study to investigated the safety and efficacy of Sintilimab plus Chidamide(SC) for patients with newly diagnosed ENKTL(SCENT-2 trial).


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04994210
Study type Interventional
Source Sun Yat-sen University
Contact Nan-qiao Cai, Professor
Phone +86 020-84115962
Email sysunsfc@mail.sysu.edu.cn
Status Recruiting
Phase Phase 2
Start date October 4, 2021
Completion date August 31, 2025

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