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NKG2D CAR-NK Cell Therapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia

Safety and Efficacy Clinical Trial

Official title:
NKG2D CAR-NK Cell Therapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia

Clinical Trial Summary

This trial will explore the maximum tolerated dose of cord blood NKG2D CAR-NK in the treatment of recurrent refractory acute myeloid leukemia in a dose-escalation manner, and observe its clinical safety and efficacy.

Clinical Trial Description

This is a single arm, open-label, Phase 1 study initiated with 3 cohorts: Cohort 1: 2×10∧6/kg CAR-NK cells, 2 infusions on Day 0 and Day 7 Cohort 2: 6×10∧6/kg CAR-NK cells, 2 infusions on Day 0 and Day 7 Cohort 3: 18×10∧6/kg CAR-NK cells, 2 infusions on Day 0 and Day 7 ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05247957
Study type Interventional
Source Hangzhou Cheetah Cell Therapeutics Co., Ltd
Contact
Status Terminated
Phase N/A
Start date October 13, 2021
Completion date December 20, 2022
View Details
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