Rotavirus Clinical Trial
Official title:
Molecular Epidemiology of Rotavirus Diarrhea Among Infants and Young Children Attending Maua Methodist Hospital, Kenya
Rotavirus is the most common cause of severe infantile diarrhoea disease in infants and young
children below five years worldwide. It is associated with high cases of morbidity and
mortality and it is estimated that up to 600,000 deaths in young children occur annually in
the less developed countries and approximately 150,000-200,000 deaths occur in Africa alone.
In Kenya, most rotavirus surveillance work has been done in Nairobi (an urban setting). Other
parts e.g eastern Kenya, limited data is available and hence the prevalence and burden of
rotavirus disease is under-estimated. We therefore hypothesize that rotavirus prevalence is
high in Meru,Maua (a rural setting)and hence we designed a study to evaluate this.
This is a prospective study to determine, the rotavirus disease burden and epidemiology in
infants and children with severe diarrhoea hospitalized in three sentinel hospital in the
eastern part of Kenya (Maua Methodist hospital) will be carried out during the period January
2009 to December 2010.
Faecal samples will be collected from infants and children admitted with acute diarrhoea and
screened first for the presence of human serotype A rotavirus antigen using commercially
available enzyme linked immunosorbent assay kit (ELISA).
The positive samples will be evaluated by sodium dodecyl polyacrylamide gel electrophoresis
(SDS-PAGE) to determine the electropherotypes and genotyped using reverse transcriptase
polymerase chain reaction (RT-PCR) on VP7 and VP4 gene.
These data/ results generated from this project will add crucial information on the rotavirus
strains circulating in the eastern part of Kenya.
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