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Rotator Cuff Injuries clinical trials

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NCT ID: NCT06414005 Recruiting - Clinical trials for Partial Thickness Rotator Cuff Tear

A Phase 2b/3 Study of TPX-115 on Partial-thickness Rotator Cuff Tear

Start date: April 15, 2024
Phase: Phase 2/Phase 3
Study type: Interventional

Rotator cuff tear is one of the most common shoulder diseases and conservative treatment is commonly used for tears involving ≤50% of tendon thickness. Since conventional conservative treatments are not fundamental to repair tendon tissue, there is a growing need of new therapy to improve structural outcome. This study assesses the safety and efficacy of allogeneic fibroblasts on partial-thickness rotator cuff tear. The primary outcome is change in Constant Score (CS) at 24 weeks after TPX-115 injection. Secondary outcomes include changes from baseline in CS, Visual Analogue Score (VAS) pain score, American Shoulder and Elbow Surgeons (ASES) score, Quick Disabilities of the Arm, Shoulder and Hand (Quick-DASH), Simple Shoulder Test (SST), and functional evaluations including Range of Motion (ROM) at 4, 12, 24 and 52 weeks after administration and structural evaluation using MRI at 24 and 52 weeks after injection.

NCT ID: NCT06407804 Recruiting - Clinical trials for Shoulder Impingement Syndrome

Effects of Thrower's Ten and Routine Physical Therapy in Patients With Shoulder Impingement Syndrome

Start date: February 1, 2024
Phase: N/A
Study type: Interventional

To compare the effects of thrower's ten and routine physical therapy on pain, range of motion and functional disability in patients with shoulder impingement syndrome

NCT ID: NCT06384430 Recruiting - Shoulder Pain Clinical Trials

Subacromial Impingement Syndrome Functional Tests Correlation With Ultrasound Parameters

Start date: April 1, 2024
Phase:
Study type: Observational [Patient Registry]

In this study, among the patients who applied to the Physical Medicine and Rehabilitation outpatient clinic of Muğla Training and Research Hospital and were diagnosed with subacromial impingement by anamnesis and clinical tests, inclusion criteria) and exclusion criteria will be included in the study. Demographic data of the patients will then be recorded. DASH (Disabilities of the Arm, Shoulder and Hand) and Constant Murley scores will be calculated. 4 years of musculoskeletal ultrasound experience will be recorded by a radiologist using ultrasound (Siemens® V8, LA2-14A probe) in modified Crass position (positioning with the palm of the examined side on the posterior iliac wing) by measuring subacromial bursa thickness, supraspinatus tendon thickness, acromiohumeral distance, supraspinatus tendon thickness/acromiohumeral distance ratio. Demographic data of the patients will then be recorded. DASH (Disabilities of the Arm, Shoulder and Hand) and Constant Murley scores will be calculated.

NCT ID: NCT06381791 Recruiting - Clinical trials for Rotator Cuff Injuries

CBD for Pain Following Orthopedic Shoulder Surgery

CBD
Start date: May 24, 2024
Phase: Phase 1/Phase 2
Study type: Interventional

The goal of the study is to learn if Epidiolex (cannabidiol) works as a additional pain medication in patients who have had orthopedic shoulder surgery. It is also to learn about safe dosages and identify any side effects after surgery. Researchers will compare Epidiolex to a placebo solution to see if Epidiolex lowers pain after shoulder surgery. Participants will: - track their pain and what medications they use every day in a provided pain diary. A researchers will call every seven days to check on the participant and diary. - Complete two short surveys. Once before surgery and once after. - Have bloodwork tested after surgery

NCT ID: NCT06329154 Recruiting - Clinical trials for Rotator Cuff Injuries

Clinical Study On Extracorporeal Shock Wave Therapy For Rotator Cuff Injuries

Start date: February 27, 2024
Phase: N/A
Study type: Interventional

This clinical trial aims to learn about the effect of extracorporeal shock wave therapy on rotator cuff injuries. The main question it aims to answer is the efficacy of extracorporeal shock wave therapy on the improvement of pain, shoulder function, and quality of life in patients with rotator cuff injuries. The experimental group of patients received extracorporeal shock wave therapy combined with conventional rehabilitation therapy. The control group only received conventional rehabilitation therapy. Compare the two groups to explore the therapeutic effect of extracorporeal shock wave therapy on rotator cuff injuries.

NCT ID: NCT06289686 Recruiting - Surgery Clinical Trials

MIRROR Project 44 - Rotator Cuff Repairs With or Without BioEnthesis™ Augmentation

Start date: March 2024
Phase: Phase 4
Study type: Interventional

Rotator cuff (RC) injuries are particularly prevalent, difficult to repair, and attachment between the bone and tendon is notoriously difficult to achieve. The most common method and current standard of care (SOC) for reattaching connective tissues (e.g., ligaments, tendons) to bone typically involves suture anchor-based techniques, but this is fraught with problems. More specifically, re-tearing of the connective tissue after this procedure occurs in 30-60% of cases, and can be even higher in patients who engage in smoking, have a diagnosis of diabetes, etc. To address these clinical challenges, Sparta Biopharma Inc. (Sparta) developed a unique technology, called BioEnthesis, to improve the connection between the tendon and bone. Pre-clinical in vivo studies demonstrated that the biphasic bovine cancellous matrix regenerated at the bone-soft tissue interface-thereby leading to high structural integrity and will likely lead to reduced re-tear rates over time. The investigators hypothesize that patients in this interventional cohort will experience enhanced mobility, reduced pain, and less re-tears after RC procedures versus a standard suture anchor-based repair.

NCT ID: NCT06272786 Recruiting - Pain Clinical Trials

Suprascapular Nerve Block in Patients Rehabilitated After Arthroscopic Rotator Cuff Repair

Start date: February 28, 2024
Phase: N/A
Study type: Interventional

Suprascapular nerve block is an injection method that has been shown to be effective in shoulder rehabilitation in diseases such as adhesive capsulitis and stroke .. Applying the block under USG guidance instead of blinding increases the effectiveness and reduces complications.

NCT ID: NCT06258278 Recruiting - Clinical trials for Massive Irreparable Rotator Cuff Tears

Clinical Results of Arthroscopic-Assisted Lower Trapezius Tendon Transfer for Massive, Irreparable Rotator Cuff Tears

Start date: October 1, 2023
Phase: N/A
Study type: Interventional

This study aimed to describe a modified technique for arthroscopic-assisted transfer of the lower trapezius tendon in a selected group of patients with irreparable rotator cuff tears and to evaluate its short-term results.

NCT ID: NCT06246305 Recruiting - Rotator Cuff Tears Clinical Trials

Effect of Virtual Reality on Upper Extremity Function Post-operative Rotator Cuff Repair

Start date: January 28, 2024
Phase: N/A
Study type: Interventional

The aim of the study is to investigate the effect and the impact of performing virtual reality intervention on upper extremity function in patients with post-operative rotator cuff repair. The main question that it aims to answer is: Does the application of virtual reality intervention improves upper extremity function in patients with post-operative rotator cuff repair. Participants will be randomized into 2 groups: the control group receiving conventional physical therapy intervention and the experimental group receiving the virtual reality intervention.

NCT ID: NCT06228625 Recruiting - Clinical trials for Rotator Cuff Syndrome

Comparison of Rehabilitative Game Exercise and Body Awareness Therapy in Rotator Cuff Syndrome

Start date: January 2, 2024
Phase: N/A
Study type: Interventional

Rotator cuff syndrome is one of the most common problems in the shoulder, starting as acute tendinopathy and progressing to partial and full thickness tears. Shoulder pain causes a decrease in shoulder joint movement, joint position sense, upper extremity function and quality of life. Among the most commonly used conservative treatment methods; Joint range of motion exercises, stretching exercises, strengthening exercises, mobilization and electrotherapy method are included. Nowadays, with the widespread use of technology in rehabilitation, video-based games have begun to be used for rehabilitative purposes in addition to conservative approaches. Although the effectiveness of video-based games has been extensively studied in diseases such as cerebral palsy, stroke and parkinsonism, there are a limited number of studies in the field of orthopedic rehabilitation, especially in shoulder rehabilitation. Basic body awareness therapy is used to treat chronic musculoskeletal-related painful conditions. In the literature, basic body awareness therapy has been studied in patient groups such as mental health, stroke patient groups, chronic musculoskeletal problems, chronic waist and neck pain, scoliosis and knee osteoarthritis. Studies have shown that the TBFT method provides improvements in individuals' body awareness, mobility in daily living activities, health-related quality of life, body image and pain intensity. However, no studies have been found in which basic body awareness therapy was used in the field of shoulder rehabilitation. Our study aims to compare the effectiveness of a rehabilitative game exercise program and body awareness training in terms of pain, joint range of motion, shoulder functionality, proprioception, body awareness, shoulder-related quality of life, kinesiophobia and patient satisfaction in individuals with Rotator cuff syndrome.