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Clinical Trial Summary

The purpose of this clinical randomized trial is to evaluate the efficacy and safety of rivaroxaban compared with warfarin in dissolving the LAA thrombus in patients with atrial fibrillation.


Clinical Trial Description

Left atrial appendage (LAA) thrombosis is a common complication of atrial fibrillation and will significantly increase the incidence of stroke in patients. Warfarin is a classical oral anticoagulant which can dissolve thrombus, but its clinical use has many limitations and it requires strict monitoring of coagulation. Recently, some studies have shown that NOAC (dabigatran / rivaroxaban) can dissolve left atrial appendage thrombosis. The application of rivaroxaban in the X-TRA study dissolved 41.5% of LAA thrombus after 6 weeks, indicating its potential clinical application prospects. Whether rivaroxaban is not inferior to warfarin for rapid dissolution of LAA thrombus, there is no prospective randomized controlled trial. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03792152
Study type Interventional
Source The Second Affiliated Hospital of Chongqing Medical University
Contact ZHIYU LING, MD
Phone +8613512362075
Email lingzy1977@163.com
Status Not yet recruiting
Phase N/A
Start date June 1, 2019
Completion date December 30, 2022

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