Right Lobe Hepatectomy Clinical Trial
Official title:
Continuous Right Thoracic Paravertebral Block on Postoperative Pain After Right Lobe Hepatectomy
Patients often experience moderate to severe postoperative pain, especially during the first
hours after hepatectomy. Systemic opioids given with patient-controlled analgesia has be
used after hepatectomy in many medical center(Aubrun, Monsel et al. 2001; Aubrun, Salvi et
al. 2005), but the analgesic effect can be limited and undesirable side effects may occur.
A case report described that right thoracic paravertebral block reduced pain and analgesic
requirements after right lobe hepatectomy(Ho, Karmakar et al. 2004). Compared with epidural
analgesia, thoracic paravertebral block probably carries a much lower risk of spinal
haematoma in the presence of moderate haemostatic deficiencies (Richardson and Lonnqvist
1998; Karmakar 2001).
We therefore designed a prospective, randomized, subject and assessor blinded,
parallel-group, placebo controlled study to test the hypothesis that continuous right
thoracic paravertebral analgesia decreases opioid consumption during the first 24 h after
right lobe hepatectomy in patients receiving i.v. patient-controlled analgesia (PCA) with
sufentanil.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment