RheumatoId Arthritis Clinical Trial
Official title:
Transplantation of Autologous Purified Bone Marrow Derived Specific Populations of Stem Cells and Mesenchymal Stem Cells in Patients With Rheumatoid Arthritis
Rheumatoid arthritis is a chronic systemic disease, which is characterized by chronic inflammation in the synovial tissue. Rheumatoid arthritis ultimately results in the destruction of cartilage, bone and ligaments and joint deformity. The underlying hypothesis is that autologous bone marrow-derived mesenchymal and specific populations of stem cells has anti-inflammatory and regenerative effects and thus potentially alleviates the progression of rheumatoid arthritis. The study is to explore the safety and efficacy of BM-SC transplantation in treatment of rheumatoid arthritis.
Rheumatoid arthritis (RA) is a chronic autoimmune disorder that primarily affects joints. It
typically results in swollen and painful joints. Pain and stiffness often worsen after rest.
Most frequently, the wrist and hands are involved, with the same joints typically involved on
both sides of the body. RA affects between 0.5-1% of adults in the developed world with
between 5-50 per 100,000 people newly developing the disease each year. Onset is most
frequent during middle age and women are affected 2.5 times as frequently as men. The goal of
treatment is to reduce pain, decrease inflammation, and improve a person's overall
functioning and quality of life.
Herein, the investigators study the safety and efficacy of the immunomodulatory effects of
bone marrow-derived stem cells administered intravenously and the regenerative and repair
potential of bone marrow-derived stem cells transplanted into the joints of patients with RA.
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