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Clinical Trial Details — Status: Active, not recruiting

Administrative data

NCT number NCT02565160
Other study ID # 15/LO/0388
Secondary ID
Status Active, not recruiting
Phase
First received
Last updated
Start date October 2015
Est. completion date October 2021

Study information

Verified date August 2019
Source Imperial College London
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Making the diagnosis underlying a painful, swollen joint currently involves aspiration followed by numerous microbiological and biochemical laboratory tests. This can be costly, time consuming and in the case of an acutely swollen joint, lead to a lengthy inpatient admission. There is an unmet need to provide a quick, easy, reliable dipstick like test to analyse joint fluid in the community, clinic, or emergency department setting.

The investigators aim to use well established metabonomic techniques to:

1. Analyse fluid from patients with swollen joints

2. Identify potential biomarkers of inflammatory, infective and osteoarthritic causes of joint swelling

3. Correlate this with lubrication and wear properties of the fluid The long term goal is to develop time saving, cost effective, non-invasive diagnostic tests to improve management of a swollen joint. The biomedical research centre at Imperial provides a unique and unparalleled clinical and scientific environment to conduct this research. The Imperial College division of Computational and Systems Medicine has an international reputation in metabonomics and this, together with the high volume of patients with swollen joints treated at Imperial National Health Service Trust (c1000/yr) ensures that the study can take place in an environment conductive to success.


Description:

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Study Design


Intervention

Procedure:
Intra-articular aspiration of Joint
Procedural sampling of the joint for diagnostic purposes
Joint irrigation washout
Procedural washout for treatment purposes
Total Joint Arthroplasty

Revision Joint Arthroplasty


Locations

Country Name City State
United Kingdom Imperial College NHS Trust London

Sponsors (1)

Lead Sponsor Collaborator
Imperial College London

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type Measure Description Time frame Safety issue
Primary Metabolic profiling of all three body fluids in 100 + patients 14 months
Secondary DNA Profiling of 100 Joint fluid samples for the assay of the microbiome 14 months
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