Role of ASICs in Human Inflammatory Pain

Rheumatoid Arthritis Clinical Trial

Official title:

Study of the Role of Acid Sensing Ion Channels (ASICs) in Human Inflammatory Pain

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01867840
• Other study ID #: 12-PP-07
• Status: Recruiting
• Phase: N/A
• First received: May 15, 2013
• Last updated: October 20, 2016
• Start date: November 2012
• Est. completion date: December 2018

Study information

• Verified date: October 2016
• Source: Centre Hospitalier Universitaire de Nice
• Contact: Véronique BREUIL, Pr
• Phone: 0492035512
• Email: breuil.v[@]chu-nice.fr
• Is FDA regulated: No
• Health authority: France: The Commission nationale de l’informatique et des libertés
• Study type: Observational

Clinical Trial Summary

In recent years, ion channels have emerged as new therapeutic targets for pain. Among these channels, ASICs (Acid Sensing Ion Channels) are of particular interest because they are directly activated by extracellular acidity, which is a major cause of pain. Indeed, many painful conditions such as ischemia, inflammation, tumor development or tissue incision are accompanied by tissue acidification. ASIC are excitatory ion channels that are expressed in neurons, including nociceptive sensory neurons. In humans, the use of amiloride, a nonspecific inhibitor of ASICs, has demonstrated their role in the perception of pain induced by subcutaneous injections of acidic solutions. ASICs thus appear as new candidates capable of mediating pain in humans. A growing number of data suggests that, in addition to protons, ASICs may also be activated by one or more endogenous compounds produced during inflammation. The purpose of this research project is to identify these compounds by testing the effects of human inflammatory exudates on ASICs activity. The discovery of such compounds would definitely validate ASICs as novel therapeutic targets for pain treatment in humans

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 20
• Est. completion date: December 2018
• Est. primary completion date: December 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• septic arthritis

• gonarthrosis in push-inflammatory

• microcrystalline arthropathies

• chronic inflammatory rheumatism

Exclusion Criteria:

• refusal to participate in the protocol

Study Design

Observational Model: Cohort

Related Conditions & MeSH terms

• Arthritis
• Arthritis, Gouty
• Arthritis, Rheumatoid
• Chondrocalcinosis
• Gouty Arthritis
• Osteoarthritis
• Rheumatoid Arthritis

Locations

Country	Name	City	State
France	Service de Rhumatologie	Nice

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Nice

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	activation or miodulation to Electrical potential of ionic channel in the synovial fluid	only once because it's an single ponction of sinovial fluid.	1 day	No