Clinical Trials Logo
  1. Home
  2. Rheumatic Disease
  3. NCT05191368

Safety and Immunogenicity of Sars-cov-2 Vaccine in Patients With Rheumatic Diseases

Rheumatic Disease Clinical Trial

Official title:
Yunnan University of Traditional Chinese Medicine

Clinical Trial Summary

The purpose of this study was to preliminarily evaluate the immunogenicity of sars-cov-2 vaccine in patients with rheumatic diseases. The clinical information collection and blood sample testing of 100 healthy people and 200 patients with rheumatic diseases will be completed in Yunnan Traditional Chinese medicine hospital. Research methods and procedures: clinical information collection and blood sample detection were carried out in healthy people and patients with rheumatic diseases, including systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), rheumatoid arthritis (RA), Sjogren's syndrome (SS), systemic sclerosis (SSC), idiopathic inflammatory myopathy (IIM), systemic vasculitis and spinal arthritis

Clinical Trial Description

Rheumatic diseases (RDS) are a large class of systemic diseases caused by genetic background, environment and physics, infection, metabolism, endocrine, immune response and other reasons, mainly involving joints and surrounding tissues. The diseases covered include systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), rheumatoid arthritis (RA) Sjogren's syndrome (SS), systemic sclerosis (SSC), idiopathic inflammatory myopathy (IIM), systemic vasculitis, spinal arthritis, etc. Patients with rheumatic diseases have an increased risk of infection due to autoimmune dysfunction and long-term use of hormones and immunosuppressants. The incidence rate of coronary heart disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) in 2019 has resulted in high incidence and mortality worldwide. Although the epidemic prevention measures such as keeping distance and quarantine isolation have effectively improved and limited the epidemic scope and the number of infected people, the groups with low immunity are still the susceptible groups of sars-cov-2. Vaccination is very important to suppress the epidemic and reduce the overall mortality. It can protect people from sars-cov-2 infection and the deterioration of covid-192, and has good safety. However, there are not enough reports on the safety and immunogenicity of sars-cov-2 vaccine in patients with rheumatic diseases. Studies have reported that the immunogenicity of sars-cov-2 vaccine is reduced in immunocompromised patients, including the use of immunosuppressive drugs. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05191368
Study type Observational
Source Yunnan University of Chinese Medicine
Contact Ting Zhao
Phone 18468146375
Email 420922691@qq.com
Status Recruiting
Phase
Start date January 12, 2022
Completion date June 1, 2022
View Details
See also
  Status Clinical Trial Phase
Completed NCT01755832 - Heated Pool Exercise Groups for Patients With Rheumatic Diseases N/A
Completed NCT04704349 - Latest Imaging SPECT System Evaluation Phase 1 N/A
Completed NCT01022905 - Vaccine Responses to Influenza A H1N1/09 Immunization in High-risk Patients Phase 4
Completed NCT00377364 - Acetaminophen (Tylenol) for Mood and Memory Changes Associated With Corticosteroid Therapy Phase 4
Completed NCT04616118 - Comparing Modes of Telehealth Delivery: Phone vs. Video Visits (ASSIST) N/A
Recruiting NCT00244153 - Intraarticular Opioids Vs Glucocorticosteroids in Gonarthritis Phase 1/Phase 2
Withdrawn NCT00346710 - Patient Experiences in Rheumatology N/A
Not yet recruiting NCT05465356 - Patient Engagement With Digital Health Tools in Rheumatology
Completed NCT00847236 - Protocol For The Quantitation Of Pain In The Diagnosis Of Polymyalgia Rheumatica N/A
Completed NCT04754698 - COVID-19 CoronaVac in Patients With Autoimmune Rheumatic Diseases and HIV/AIDS Phase 4
Completed NCT03454438 - Strategies to Improve Appropriate Referral to Rheumatologists N/A
Terminated NCT03186794 - Aerobic Exercise in Women With Systemic Lupus Erythematosus N/A
Active, not recruiting NCT05283096 - Survey About Diet in Chronic Inflammatory Rheumatic Diseases
Completed NCT05321901 - Telerehabilitation in Women With Rheumatic Disease N/A
Recruiting NCT02504879 - Natural History, Pathogenesis and Outcome of Melorheostosis A Rare Osteosclerotic Disease
Recruiting NCT01685905 - The Usefulness of Interferon-γ Release Assays and Tuberculin Skin Test for Detection of Latent Tuberculosis Infection N/A
Recruiting NCT06004349 - Autoimmune and Autoinflammatory Genetics Study