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Reward Mediating System clinical trials

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

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NCT ID: NCT01950377 Completed - Clinical trials for Reward Mediating System

Imaging and Genetic Investigation of Learning and Decision Making

Start date: February 11, 2014
Phase:
Study type: Observational

Background: - Previous research has shown that dopamine, a brain chemical, is involved in decision making. Different genes influence how much dopamine people have in their brains and how that affects their behavior. Researchers will study if genes associated with dopamine affect decision making and impulsiveness. All participants will take tests; some will have brain images taken. Researchers will study the test responses and images; they will look for how differences in these genes affect different types of decision making. Objectives: - To see if genes involved in a brain chemical, dopamine, are related to impulsiveness on behavioral tests. Eligibility: - Healthy adults ages 18 to 55. Design: - Participants will be screened with a medical history and physical exam. - All participants in this study will have at least 1 outpatient visit to the NIH Clinical Center. Each visit will last 2 4 hours. At the first visit: - A blood sample will be taken only from participants that have not been previously enrolled in 95-M-0150 - Participants will be given tests of their memory, attention, concentration, and thinking. - Some participants will have a second visit. It will be scheduled as soon as possible after the first. At the second visit: - Participants will have an MRI (magnetic resonance imaging). They will have to lie in a scanner for up to 2 hours. The MRI uses magnets, radio waves, and computers to produce detailed pictures of the brain. - Participants will repeat the tests from the first visit. Some will be done during the MRI.