Direct Pulp Capping Agent on Human Pulp Tissue

Status Recruiting

Clinical Trial Summary

This in- vivo study was conducted to evaluate the response of human pulp tissue following direct pulp capping using four different pulp capping agents in premolars scheduled for extraction in patients undergoing orthodontic treatment.

Clinical Trial Description

For the study 40 premolars from patients in the age group of 15-25 years, undergoing orthodontic treatment, in the Department of Orthodontics, MMCDSR, Mullana, Ambala, who had to get their premolars extracted as per their orthodontic treatment plan will be selected. Only healthy premolars, with no caries, showing no signs and symptoms of pulpitis or periodontal diseases were selected. Medically compromised patients, or teeth with radiographic findings of external/internal resorption, bone loss, or calcifications in the pulp chamber will be excluded from the study. The selected premolars were then randomly divided into four equal groups namely: GROUP I - Direct pulp capping procedure performed using Biodentine. GROUP II - Direct pulp capping procedure performed using MTA. GROUP III - Direct pulp capping procedure performed using TheraCal LC. GROUP IV - Direct pulp capping procedure performed using Tristrontium aluminate. The direct pulp capping procedure was carried out under rubber dam. The study protocol included class I cavity preparations on the premolars, followed by iatrogenic exposure of the pulp (0.5mm) using a sterile round bur, placement of the direct pulp capping agent according to the material of allotted to the study group. The teeth were permanently restored on the same visit, except for MTA group were the teeth were temporarily restored using Cavit G, and recalled after 1 day for permanent restoration. The patients were then enquired for any 94 SUMMARY 95 symptoms at 1 day and 7 days post operatively. The teeth were then, atraumatically extracted 3 months after the procedure. The extracted teeth were then put to CBCT as well as histopathological examination. Through CBCT evaluation, the completeness of the dentine bridge was evaluated. Histopathological examination was done to examine the pulpal response and the quality of the dentine bridge formed ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06435065
Study type	Interventional
Source	Maharishi Markendeswar University (Deemed to be University)
Contact	swati chhabra, MDS
Phone	7015070095
Email	drswatichhabra@gmail.com
Status	Recruiting
Phase	Phase 4
Start date	April 1, 2024
Completion date	July 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05167123` - Pulp Capping in Primary Molars Using TheraCal (LC)	Phase 4
Recruiting	`NCT05144711` - Management of Deep Carious Lesions in Adults	N/A
Completed	`NCT01224925` - RCT of Pulp Capping Over Carious Exposure in Adults	N/A
Completed	`NCT03284697` - Direct Pulp Capping With MTA and Calcium Hydroxide.	N/A
Completed	`NCT03286959` - Effect of Liners on Pulpal Outcome and Restoration Survival After Partial Caries Excavation	N/A
Completed	`NCT04167943` - Conservative Pulp Therapy of Primary Molars Using TheraCAL	Phase 3
Enrolling by invitation	`NCT02702505` - Success and Color Stability of MTA Pulpotomized Primary Molars: an RCT	Phase 4
Active, not recruiting	`NCT05878249` - Role Of Wound Lavage in Direct Pulp Capping Of Permanent Teeth With Carious Exposure	N/A
Not yet recruiting	`NCT06433297` - Comparative Evaluation of Indirect vs. Direct Pulp Capping in Deep Carious Mandibular Molars	N/A
Not yet recruiting	`NCT04617600` - Survival Rate After TheraCal PT Pulpotomy Versus MTA Pulpotomy in Children With Vital Primary Molars.	N/A
Terminated	`NCT01622153` - Electrical and Formocresol Pulpotomy in Primary Molars	N/A
Active, not recruiting	`NCT03186690` - Similar Outcomes of Vital Pulp Therapy Using Mineral Trioxide Aggregate or Biodentine™	N/A
Active, not recruiting	`NCT03071588` - Assessment of a New Protocol for Indirect Pulp Capping Procedures	N/A
Active, not recruiting	`NCT02201641` - Efficacy of Calcium Silicate Pulp-capping; a Randomized Controlled Clinical Trial	Phase 4
Recruiting	`NCT03741816` - Indirect Pulp Capping With Biodentine and TheraCal LC in Permanent Mature Molars	N/A
Completed	`NCT04365270` - Antibacterial Effect and Clinical Performance of Chitosan Modified Glass Ionomer	Phase 3
Completed	`NCT05145686` - The Role of Matrix Metalloproteinases on the Primary Teeth Pulpotomy Treatments	Phase 1/Phase 2
Completed	`NCT00187837` - The CAP-1 Trial: Stepwise Excavation Versus One Completed Excavation in Deep Caries	N/A
Active, not recruiting	`NCT04374214` - Effect of Simvastatin as Pulpotomy Agent in Cariously Exposed Permanent Molars	N/A
Not yet recruiting	`NCT04807244` - Treatment of Deep Carious Lesions With Selective Caries Removal, Partial or Full Pulpotomy	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.