Rett Syndrome Clinical Trial
Official title:
Pathogenesis of Rett Syndrome: Natural History and Treatment
Rett syndrome (RTT) is a disorder in which the nervous system does not develop properly. RTT generally affects girls, but there are some boys who have been diagnosed with RTT. Symptoms of RTT include small brain size, poor language skills, repetitive hand movements, and seizures. This study will evaluate the effectiveness of two drugs in treating the symptoms of RTT.
Status | Recruiting |
Enrollment | 90 |
Est. completion date | June 2008 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 1 Year to 15 Years |
Eligibility |
Inclusion Criteria - Diagnosis of Rett syndrome - Mutation in MeCP2 gene - Typical EEG abnormalities (disorganized background, frontal central spikes, rhythmic theta) Exclusion Criteria - Features of Rett syndrome with absence of MeCP2 mutation - Non-specific EEG changes |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United States | Kennedy Krieger Institute | Baltimore | Maryland |
Lead Sponsor | Collaborator |
---|---|
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
United States,
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