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NCT06368375 Clinical Trial

Clinical and Genetic Findings in Patients With PRPF31-associated Retinitis Pigmentosa

Retinitis Pigmentosa Clinical Trial

Official title:
Clinical and Genetic Findings in Patients With PRPF31-associated Retinitis Pigmentosa

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT06368375
Other study ID # PRPF31-3102022BO2
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2023
Est. completion date June 30, 2023

Study information
Verified date March 2024
Source University Hospital Tuebingen
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Retrospective chart review study to elucidate the genotype and phenotype of patients with PRPF31-associated retinitis pigmentosa and asymptomatic carriers of the respective variant(s)

Recruitment information / eligibility
Status Completed
Enrollment 87
Est. completion date June 30, 2023
Est. primary completion date June 30, 2023
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - genetically confirmed PRPF31-associated inherited retinal dystrophy or asymptomatic carrier of the respective variant(s) Exclusion Criteria: - none

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Germany University Hospital Tuebingen Tuebingen Baden-Wuerttemberg

Sponsors (1)
Lead Sponsor Collaborator
University Hospital Tuebingen

Country where clinical trial is conducted

Germany, 

Outcome
Type Measure Description Time frame Safety issue
Primary Best Corrected Visual Acuity (BCVA) best corrected visual acuity September 2007 - January 2022
Primary Visual Field (VF) visual field as measured by semi-automated 90° kinetic visual field exam using target III4e September 2007 - January 2022
Primary Fundus Photography (FP) characterization of the retina with fundus photography September 2007 - January 2022
Primary Optos characterization of the retina with ultra-wide-field scanning laser ophthalmoscopy September 2007 - January 2022
Primary Autofluorescence (AF) characterization of the retina with fundus autofluorescence September 2007 - January 2022
Primary Optical Coherence Tomography (OCT) characterization of the retina with optical coherence tomography, e.g. foveal ellipsoid zone loss September 2007 - January 2022
Primary Full-Field Electroretinogram (ff-ERG) characterization of retinal function with full-field electroretinogram September 2007 - January 2022
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