Retinal Vascular Clinical Trial
Official title:
Physiologic Change of Posterior Ocular Segment During Pregnancy
Women's physiology changes markedly during normal pregnancy. The most distinct alterations occur in the hormonal and cardiovascular systems. There is a dramatic increase in both estrogen and progesterone. Blood volume starts to increase in the first gestational period and reaches a peak in the third trimester. The physiologic ocular changes during pregnancy are mainly the result of hormonal and blood volume increase, and then are usually marked in the third trimester.
Status | Not yet recruiting |
Enrollment | 69 |
Est. completion date | June 30, 2026 |
Est. primary completion date | December 30, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Healthy pregnant women - Age > 18 years - Gestational age < 12 weeks - Written informed consent Exclusion Criteria: - High risk pregnancy such as multifetal pregnancy and preeclampsia - History of vitreoretinal diseases such as retinal vasculitis - History of intraocular laser treatments or intraocular surgeries - History of systemic diseases such as diabetes mellitus and thyroid disease - Refractive error; spherical equivalence > 4 diopters - Clear ocular media - Could not be taken the images by non-dilated pupil Withdrawal Criteria: - Preterm labor; gestational age < 34 weeks - Multifetal pregnancy was demonstrated by ultrasound - Severe labor and delivery complications such as - Severe postpartum complications such as postpartum bleeding - Taking hormone during the follow-up period |
Country | Name | City | State |
---|---|---|---|
Thailand | Khon Kaen University | Khon Kaen |
Lead Sponsor | Collaborator |
---|---|
Khon Kaen University |
Thailand,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Retinal vascular density | % of retinal vascular density is measured by optical coherence tomography angiography | 40 weeks | |
Secondary | Choroidal thickness | Choroidal thickness (um) is measured by optical coherence tomography | 40 weeks | |
Secondary | Retinal nerve fiber layer thickness | Retinal nerve fiber layer thickness (um) is measured by optical coherence tomography | 40 weeks | |
Secondary | Optic disc tomography | Cup area and disc area (mm3) are measured by optical coherence tomography | 40 weeks |
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