Physiologic Change of Posterior Ocular Segment During Pregnancy

Status Not yet recruiting

Clinical Trial Summary

Women's physiology changes markedly during normal pregnancy. The most distinct alterations occur in the hormonal and cardiovascular systems. There is a dramatic increase in both estrogen and progesterone. Blood volume starts to increase in the first gestational period and reaches a peak in the third trimester. The physiologic ocular changes during pregnancy are mainly the result of hormonal and blood volume increase, and then are usually marked in the third trimester.

Clinical Trial Description

Ocular anterior segment changes during pregnancy are the followings - Melanogenesis of eyelid and facial skin -> melasma - Cellular alteration of lacrimal and meibomian gland -> dry eye symptoms - Increased corneal thickness and corneal curvature -> contact lens intolerance - Increased lens thickness -> loss of accommodation - Decreased intraocular pressure -> better glaucoma control There are few studies of posterior changes in pregnant women. Many limitations of previous publications includes lack of internal control and no data of postpartum contraception. However, choroidal thickness seems to be thicker in pregnant women than non-pregnant women. The other changes are non-inclusive. ;

Study Design

Related Conditions & MeSH terms

Retinal Vascular

Clinical Trial Details

NCT number	NCT04731415
Study type	Interventional
Source	Khon Kaen University
Contact	Suthasinee Sinawat, MD
Phone	+66 81 5454594
Email	ssuthasinee@kku.ac.th
Status	Not yet recruiting
Phase	N/A
Start date	July 1, 2021
Completion date	June 30, 2026

View Details

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