Resting Energy Expenditure Clinical Trial
Official title:
Effects of Micellar Solubilized Xanthohumol on Resting Energy Expenditure and Substrate Oxidation in Healthy Women
NCT number | NCT05711212 |
Other study ID # | XN REE |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | February 15, 2023 |
Est. completion date | April 30, 2024 |
Verified date | May 2024 |
Source | University of Bonn |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The aim of this study is to investigate the effects of Xanthohumol on resting energy expenditure and substrate oxidation in healthy women. It is assumed that resting energy expenditure and fatty acid oxidation is higher after Xanthohumol ingestion.
Status | Completed |
Enrollment | 16 |
Est. completion date | April 30, 2024 |
Est. primary completion date | April 30, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 35 Years |
Eligibility | Inclusion Criteria: - BMI: 18,5 - 24,9 kg/m2 - metabolically healthy - written consent Exclusion Criteria: - smoking - low or high blood pressure - dyslipidemia - insulin resistance or diabetes mellitus type 1 or type 2 - gastrointestinal diseases (e.g. food intolerances or allergies) - liver, kidney and/or thyroid diseases - hepatitis B or C, HIV Infection - chronic inflammatory diseases - disordered eating - psychological diseases - alcohol and/or drug abuse - use of medication - pregnancy or lactating - participation in another intervention study - irregular menstrual cycle - more than 6 hours of sports per week |
Country | Name | City | State |
---|---|---|---|
Germany | University of Bonn | Bonn |
Lead Sponsor | Collaborator |
---|---|
University of Bonn |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Acute Effect on Resting Energy Expenditure | calculated from Volume of inhaled oxygen (VO2) in L/min and exhaled carbon dioxide (VCO2) in L/min, given in kcal/24 hours | assessed uninterrupted for 3 hours post dose | |
Primary | Prolonged Effect on Resting Energy Expenditure | calculated from Volume of inhaled oxygen (VO2) in L/min and exhaled carbon dioxide (VCO2) in L/min, given in kcal/24hours | assessed uninterrupted for 30 minutes 24 h post dose | |
Primary | Acute Effect on Substrate Oxidation | assessed by the respiratory quotient (RQ=VCO2/VO2), given in percent | assessed uninterrupted for 3 hours post dose | |
Primary | Prolonged Effect on Substrate Oxidation | assessed by the respiratory quotient (RQ=VCO2/VO2), given in percent | assessed uninterrupted for 30 minutes 24 h post dose | |
Secondary | Acute Effect on Blood pressure | given in millimeter mercury | 0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180 minutes post dose | |
Secondary | Prolonged Effect on Blood pressure | given in millimeter mercury | 24 hours, 24 hours and 10 minutes, 24 hours and 20 minutes, 24 hours and 30 minutes post dose | |
Secondary | Acute Effect on Pulse | given in beats per minute | 0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180 minutes post dose | |
Secondary | Prolonged Effect on Pulse | given in beats per minute | 24 hours, 24 hours and 10 minutes, 24 hours and 20 minutes, 24 hours and 30 minutes post dose |
Status | Clinical Trial | Phase | |
---|---|---|---|
Suspended |
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