Metabolic Effects of Differential Organ Growth Rates

Status Completed

Clinical Trial Summary

Young children have a high resting energy expenditure (REE) relative to their body weight and metabolically active compartment, fat-free mass (FFM). Both body weight and FFM are, however, metabolically heterogeneous and include organs and tissues varying widely in specific metabolic rate (i.e., organ REE/kg/d). One prevailing hypothesis is that most, if not all, of the higher REE observed in young animals and children compared to adults can be accounted for by a larger proportion of high metabolic rate components such as brain, liver, and heart..

Clinical Trial Description

FFM was the traditional and only means of adjusting REE for between-individual differences in metabolically active tissue components. The investigators seek to improve the understanding of variation in REE by developing new and improved rapid magnetic resonance imaging (MRI) methods of quantifying some of the major heat producing organs and tissues in children and adults. The long-term aim is to provide an improved understanding of human energy requirements. Specifically, the investigators propose to test whether: 1) a portion of the elevated daily REE adjusted for FFM observed in young children (Tanner Stage 1) could be accounted for by the relative fractions of body mass as high metabolic activity tissues (heart, liver, kidney, brain) and low metabolic activity tissues (skeletal muscle, adipose tissue), 2) a portion of the age-related decline in daily REE adjusted for FFM observed in children could be accounted for by changes in the relative fractions of body mass as high and low metabolic rate tissues during growth. ;

Study Design

Related Conditions & MeSH terms

Resting Energy Expenditure

Clinical Trial Details

NCT number	NCT03219229
Study type	Observational
Source	Columbia University
Contact
Status	Completed
Phase	N/A
Start date	February 14, 2004
Completion date	February 20, 2007

View Details

See also
Status	Clinical Trial	Phase
Suspended	`NCT04474587` - Resting Energy Expenditure in Patients With OHS Treated With Long-term NIV
Completed	`NCT04766021` - Mirabegron and Physiological Function in Cold Environments	Phase 1/Phase 2
Completed	`NCT05505240` - Influence of Ambient Temperature on Resting Energy Expenditure of Healthy Adults	N/A
Not yet recruiting	`NCT06377943` - The Interaction Between Resting Metabolic Rate, Physical Activity and Thyroid Hormone in Females
Completed	`NCT04947839` - Novel Equation for Estimating Resting Energy Expenditure in Dialysis Patients
Completed	`NCT01595191` - Bach Music in Preterm Infants: No "Mozart Effect" on Resting Energy Expenditure	N/A
Completed	`NCT05990387` - MIrabegron and Physiological Function in Cold Environments	Phase 1/Phase 2
Completed	`NCT03569852` - Time Restricted Feeding in Male Runners	N/A
Completed	`NCT03193632` - Predicting Resting Energy Expenditure in Critically Ill Patients by Measuring Lean Body Mass by US
Completed	`NCT05711212` - Effects of Xanthohumol on Resting Energy Expenditure and Substrate Oxidation in Healthy Women	N/A
Completed	`NCT03377413` - Novel Equation for Estimating Resting Energy Expenditure
Recruiting	`NCT04500483` - Indirect Calorimetry in Patients at Risk of Malnutrition
Recruiting	`NCT03511950` - The Relationship Between the Change of Resting Energy Expenditure and Nutritional Status .