Respiratory Insufficiency Clinical Trial
Official title:
Innovation Against Infection - Device Related Infections - Part ETT
Three endotracheal tubes (ETTs) with different surfaces properties will be studied regarding
formation and structure of the biofilm formed on those ETTs.
Cultures from oropharynx and tracheal secretions as well as pieces of the ETT will be
examined.
Findings from electron microscopy (EM) and microbiology will be analyzed and compared in
respect to the three materials.
Ventilator associated pneumonia (VAP) is a frequent and costly complication to mechanical
ventilation in critically ill patients. Aspiration of oropharyngeal secretions and fragments
of biofilm from the endotracheal tube are the main causes of VAP.
It is well known that biofilm is formed on medical devices and several initiatives to reduce
the development of such biofilms have been taken. However it is still a large clinical
problem and colleagues have performed studies to find out the structure of the biofilms
formed on the ETT and to what extent microbiological findings correlate to images from EM.
In this study the investigators will compare microbiology and EM images in that same manner.
Three different ETTs will be examined. The investigators will be using each of the three ETTs
for a period of time sufficient to retrieve samples from at least 20 ETTs of each kind.
Only one kind of ETT will be used during the specified time period, no randomization. The
test will be performed in the order mentioned below A - B - C All of the three tubes are
CE-marked (Conformité Européenne) and are available on the market.
ICU patients needing mechanical ventilation will be intubated with the three different
devices with different surfaces characteristics.
The tubes are: A - standard Poly vinyl chloride (PVC) tube; B - PVC with a silicon coating; C
- PVC with a special metal film coating
;
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