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Influence Positive End-expiratory Pressure on Autoregulation in Patients With Respiratory Insufficiency — dARICUPEEP  

Respiratory Insufficiency Clinical Trial

Official title:
Influence of Positive End-expiratory Pressure on the Cerebrovascular Autoregulation in Patients With Respiratory Failure

Clinical Trial Summary

The aim of the present study is to characterize the influence of an elevated positive end-expiratory pressure in patients with acute respiratory distress syndrome or acute lung injury on the cerebrovascular autoregulation.

Clinical Trial Description

Cerebral blood flow velocity will be measured using transcranial Doppler sonography and then correlate with the invasive arterial blood pressure curve to calculate the index of cerebrovascular autoregulation Mx (Mx>0.3 indicates impaired AR). The index of cerebrovascular autoregulation Mx was measured during baseline positive end-expiratory pressure (PEEP) levels and after lung recruitment with higher level of PEEP. The equality between this two PEEP levels was estimated and calculated with one side Wilcoxon test. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01376518
Study type Observational
Source Johannes Gutenberg University Mainz
Contact
Status Completed
Phase
Start date January 2011
Completion date June 2011
View Details
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