Role of High Flow Nasal Oxygen as a Strategy for Weaning From Invasive Mechan

Respiratory Failure With Hypoxia Clinical Trial

Official title: Role of High Flow Nasal Oxygen as a Strategy for Weaning From Invasive Mechan

Status Not yet recruiting

Clinical Trial Summary

evaluate the Efficacy of high flow nasal oxygen as a weaning strategy in mechanically ventilated patients with respiratory failure.

Clinical Trial Description

Acute respiratory failure is a main cause of IMV and admission to intensive care unit (ICU){1}.

The day of extubation is a critical time during an intensive care unit (ICU) stay because in case of postextubation failure {2},which reach to 25 - 40% from extubated patient associated with VAP and barotrauma, mortality rate and hospital stay will increase , we use Adjuvant oxygen therapy to prevent these undesirable event like COT ,NIV and High-flow nasal cannula (HFNC) which can be used as an initial weaning strategy from IMVdue to its physiologic benefits [3-4].

HFNC devices supply between 30 and 60 L/min of a controlled mixture of actively warmed (32-37 °C) and humidified (up to 100% relative humidity) oxygen and air through modified nasal prongs. producing {5-6-7}:

1. moderate positive end-expiratory pressure (PEEP) .

2. HFNC might help prevent extubation failure through different

Mechanisms:

1. First, the controlled oxygen concentration may reduce transient hypoxemic episodes .

2. Second, the high flow washes the nasopharyngeal dead space, thus reducing CO2 re-breathing; this effect reduces respiratory rate and minute ventilation .

3. Third, the small amount of PEEP may reduce lung collapse . c)enabling better gas exchange and reduced work of breathing. d)in patients with chronic obstructive pulmonary disease (COPD), this level of PEEP may counterbalance auto PEEP, further reducing the work of breathing.

e) humidification may improve mucus drainage and reduce mucus retention, alleviating the associated atelectasis. ;

Related Conditions & MeSH terms

• Hypoxia
• Respiratory Failure With Hypoxia
• Respiratory Insufficiency

• NCT number: NCT04657796
• Study type: Observational
• Source: Assiut University
• Contact: Hamed Fr Qenawy, Bachelor
• Phone: 01061812045
• Email: hamedfarrag216@gmail.com
• Status: Not yet recruiting
• Start date: December 5, 2020
• Completion date: December 4, 2023