Respiratory Failure With Hypoxia Clinical Trial
— VOLHYPOXOfficial title:
Assessment of Tidal Volume by Electrical Impendance Tomography During Non Invasive Oxygenation Techniques in de Novo Hypoxemic Acute Respiratory Failure
High Tidal volume is one of the main mechanisms that lead to lung injuries under mechanical ventilation (ventilator induced lung injury: VILI). It could also induce lung damage during spontaneous or assisted ventilation (patient-self inflicted lung injury: P-SILI). Different non invasive oxygenation devices are available to deliver oxygen during acute hypoxemic respiratory failure: high concentration mask, high flow nasal canula and non-invasive ventilation (with bucco-nasal mask or helmet). The investigators hypothesized that the device may influence the tidal volume. Therefore, the objective of this study is to measure and compare the tidal volume during the use of each device. Tidal volume will be measured using Electrical impedence tomography.
Status | Not yet recruiting |
Enrollment | 25 |
Est. completion date | September 1, 2019 |
Est. primary completion date | June 30, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Respiratory rate > 25 per minute - PaO2/FiO2 < 200 mmHg - PaCO2 < 45 mmHg - Signed consent by patient or relative Exclusion Criteria: - Chronic respiratory disease - COPD exacerbation - Acute asthma - Cardiogenic pulmonary edema - Hemodynamic instability (systolic blood pressure < 90 mmHg or mean blood pressure < 65 mmHg or use of catecholamines) - Coma (Glasgow coma scale < 12) - Contraindication to non-invasive ventilation - Indication to immediate intubation according to the physician |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Henri Mondor University Hospital |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Tidal volume | in milliliter | Averaged value over the last 3 minutes of thoracic impedance recording | |
Secondary | pH | Arterial blood gases will be collected only if an arterial catheter will be already inserted | After 15 minutes of using a non invasive oxygenation device | |
Secondary | PaO2 | in mm Hg; Arterial blood gases will be collected only if an arterial catheter will be already inserted | After 15 minutes of using a non invasive oxygenation device | |
Secondary | PaCO2 | in mm Hg; Arterial blood gases will be collected only if an arterial catheter will be already inserted | After 15 minutes of using a non invasive oxygenation device | |
Secondary | Respiratory rate | in cycle/min | After 15 minutes of using a non invasive oxygenation device | |
Secondary | Comfort | using a semiquantitative scale from 1 (the worst comfort) to 5 (the best comfort) | After 15 minutes of using a non invasive oxygenation device | |
Secondary | Regional Tidal volume | in milliliter | Averaged value over the last 3 minutes of thoracic impedance recording | |
Secondary | Global inhomogeneity index | in percentage | Averaged value over the last 3 minutes of thoracic impedance recording |
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