Superselective Adrenal Arterial Embolization for Resistant Hypertension

Status Not yet recruiting

Clinical Trial Summary

Resistant hypertension (RH) is usually defined as blood pressure (BP) that remains above guideline-specified targets despite the use of three or more antihypertensive agents at optimal or maximally tolerated doses, with one of those agents preferably being a diuretic. It is not uncommon, being identified in 10 to 30% of hypertensive patients and it is known to be a risk factor for cardiovascular (CV) events, including stroke, myocardial infarction (MI), heart failure (HF), and CV mortality, as well as adverse renal events,including chronic kidney disease (CKD) and end-stage kidney disease (ESKD). The activation of the renin-angiotensin-aldosterone system (RAAS) and sympatho-adrenomedullary system can play a pathogenic role in triggering and sustaining RH. SAAE is a catheter-based percutaneous transluminal procedure which selectively injects ethanol into adrenal artery to ablate part of the adrenal gland for suppression of excessive aldosterone and catecholamines. Therefore, SAAE is a minimally invasive procedure that might be used as an alternative strategy to antihypertensive drugs or reduce the intensity of antihypertensive drugs.

Clinical Trial Description

Not Provided ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05552300
Study type	Interventional
Source	First Affiliated Hospital of Chengdu Medical College
Contact	Yaqiong Zhou, MD
Phone	+8615184399329
Email	1273868593@qq.com
Status	Not yet recruiting
Phase	N/A
Start date	October 1, 2022
Completion date	March 31, 2025

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