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Clinical Trial Summary

This study aims to explore the efficacy and safety of remote ischemia adaptation for the treatment of resistant hypertension.


Clinical Trial Description

Resistant hypertension is defined as a blood pressure of 140/90 mmHg or higher despite adherence to at least three antihypertensive drugs (including one diuretic), accounting for 20% to 30% of patients with hypertension. Compared with patients with well-controlled blood pressure, the cardiovascular risk of resistant hypertension is increased by about 50%. Limb remote ischemic conditioning (LRIC) triggers endogenous protective effects through transient and repeated ischemia in the limb to protect remote tissues and organs. The mechanisms of LRIC involve the regulation of the autonomic nervous system, the release of humoral factors, improvement of vascular endothelial function, and modulation of immune/inflammatory responses, which can antagonize the pathogenesis of hypertension through multiple pathways to lead to a drop in BP theoretically. This theory has been preliminarily confirmed by several small sample-size studies in non-resistant hypertension. This study aims to explore the efficacy and safety of remote ischemia adaptation for the treatment of resistant hypertension. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05426707
Study type Interventional
Source Capital Medical University
Contact Xunming Ji, MD, PhD
Phone 83199430
Email jixm@ccmu.edu.cn
Status Not yet recruiting
Phase N/A
Start date October 1, 2022
Completion date March 30, 2023

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